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Phenotype Image Detail
Image
Caption Transmission electron micrographs of FDL (flexor digitorum longus) tendons at P4 and P60 from wild-type (Col14a1 +/+) and Col14a1tm1Debi/Col14a1tm1Debi (Col14a1 -/-) mice. At P4, tendon fibroblasts are surrounded by small collagen fibers (fibril bundles) (*). The wild-type collagen fibers are uniform in shape, whereas the mutant bundles are more irregular. In addition, the fibroblast and the compartments defined by their processes are disrupted in the mutant tendon relative to the organized wild-type controls. At P60, the collagen fibers are much larger than at P4 are defined by attenuated fibroblast processes (arrows). There is comparable structure and organization in wild-type and mutant tendons at this mature time point when type XIV collagen is not expressed in wild-type mice. Bar, 3 um.
Copyright This image is from Ansorge HL, J Biol Chem 2009 Mar 27;284(13):8427-38 and is displayed with the permission of the American Society for Biochemistry and Molecular Biology who owns the Copyright. Full text from JBC. J:148619
Associated
Alleles
Symbol Name
Col14a1tm1Debi collagen, type XIV, alpha 1; targeted mutation 1, David E Birk
Associated
Genotypes
Allelic Composition Genetic Background
Col14a1tm1Debi/Col14a1tm1Debi involves: 129S4/SvJae * C57BL/6

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
02/16/2021
MGI 6.16
The Jackson Laboratory