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Caption Light micrographs of epididymal tubules of wild-type and Fshrtm1Saco/Fshrtm1Saco mice. Wild-type (A,C,E) and Fshrtm1Saco/Fshrtm1Saco (B,D,F) mice at 3 (A-D) and 6 (E,F) months of age of the initial segment (A,B,E,F) and caput (C,D). Note the full complement of epithelial cells, composed mainly of principal cells (P), in both wild-type and mutants (compare, A,C,E-B,D,F). Also note the presence of sperm within the lumen (Lu) of the tubules in both wild-type and mutants. Tissues were fixed either by glutaraldehyde (A-B) or Bouin's Fixative (C-F). A reduction in tubular size is evident in mutant tubules (B,D,F), as well as the epithelial compartment (B,D,F) compared to wild-type (A,C,E). Immunostaining with an anti-androgen receptor antibody (C-F) revealed a checkerboard staining pattern within the nuclei of principal cells (C-F) comparable between mutant (D,F) and wild-type (C,E). While some nuclei were intensely reactive (arrows), others were moderately reactive (arrowheads) or unreactive (curved arrows). Immunostaining with anti-clusterin antibody revealed a checkerboard staining of principal cells (P) comparable between both wild-type (E) and mutant (F). While some cells stain intensely (arrows), others are moderately reactive (arrowheads) or unreactive (curved arrows). Similar staining was observed in 3 month old mutant and wild-type tissue (not shown). IT, Intertubular space. Original magnification: A-D, 390x; E-F, 250x.
Copyright This image is from Grover A, Mol Reprod Dev 2005 Oct;72(2):135-44, and is displayed with the permission of Wiley-Blackwell, who owns the Copyright. J:137005
Symbol Name
Fshrtm1Saco follicle stimulating hormone receptor; targeted mutation 1, Paolo Sassone-Corsi
Allelic Composition Genetic Background
Fshrtm1Saco/Fshrtm1Saco involves: 129/Sv

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