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Phenotype Image Detail
Caption Electron micrographs of sperm within the cauda epididymidis of 12 month old wild-type (inset) and Fshrtm1Saco/Fshrtm1Saco (FORKO, A-E) mice. In wild-type mice (A inset), the sperm head appears smooth and tubular or elongated in profile and cytoplasm enveloping the head is attenuated with no prominent organelles; the chromatin is condensed within the nucleus (N) and the acrosome (A) is closely applied to it (inset). Cytoplasm surrounding sperm tails (T) reveals the presence of a single axoneme and associated structures. In mutant mice, the nucleus (N) is often distorted or lobulated (A,B,E). The acrosome (A) shows a peeling off configuration (B,C). In mutant mice (B-E), the cytoplasm surrounding the head is prominent and contains vacuoles (V), membranous profiles (curved arrow), mitochondria (open stars), and several cross sectional profiles of tails (T), none of which are encountered in wild-type mice. Tails of sperm show a central axoneme, outer dense fibers and enveloping mitochondria (small arrowheads). Some sperm heads (E) are associated with a moderately dense amorphous material (dense stars). In the lumen of mutant mice (D), some cross sections of tails (T) show a double axoneme and associated structures enveloped by a commom cytoplasm. Original magnification: Inset, 10,465x; (A) 28,175x; (B) 35,525x; (C) 14,950x; (D) 9,315x; (E) 15,180x.
Copyright This image is from Grover A, Mol Reprod Dev 2005 Oct;72(2):135-44, and is displayed with the permission of Wiley-Blackwell, who owns the Copyright. J:137005
Symbol Name
Fshrtm1Saco follicle stimulating hormone receptor; targeted mutation 1, Paolo Sassone-Corsi
Allelic Composition Genetic Background
Fshrtm1Saco/Fshrtm1Saco involves: 129/Sv

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