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Phenotype Image Detail
Image
Caption Ventricular and atrial septal defects. A: Transverse sections through the thorax of Hey2tm1Gess/Hey2tm1Gess (-/-) and Hey2+/Hey2tm1Gess (+/-) embryos at stages E12.5, E13.5, E14.5 and E16.5. While all homozygous hearts exhibit a ventricular septal defect (VSD, arrowhead), only E12.5 heterozygotes presented with a VSD that is physiological at this stage. B: An isolated VSD at stage E16.5 in a CD1 background homozygous mutant mouse similar to VSDs seen in C57BL/6 mice. C: Transverse heart sections of a homozygous mutant mouse 5 days after birth showing a VSD combined with a persistent foramen ovale (arrow, right). In control animals the foramen ovale had closed at this time point. The aorta rides over both ventricles (left). LV, RV: left, right ventricle; LA, RA, left, right atrium; IVS: interventricular septum.
Copyright This image is from Fischer A, Mamm Genome 2004 Sep;15(9):711-6 and is displayed with the permission of Springer Science + Business Media, Inc., New York who owns the copyright. J:93980
Associated
Alleles
Symbol Name
Hey2tm1Gess hairy/enhancer-of-split related with YRPW motif 2; targeted mutation 1, Manfred Gessler
Associated
Genotypes
Allelic Composition Genetic Background
Hey2tm1Gess/Hey2tm1Gess B6.129P2-Hey2tm1Gess
Hey2tm1Gess/Hey2tm1Gess involves: 129P2/OlaHsd * CD-1

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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
12/11/2018
MGI 6.13
The Jackson Laboratory