Phenotype Image Detail

Image

Caption

Sinus and ear inflammation. A and B: Hematoxylin and eosin staining of sinus sections from adult wild-type (control, A) and Cby1^tm1Ktkm/Cby1^tm1Ktkm (KO, B) mice. Asterisks label accumulation of protein-rich fluid. C and D: Hematoxylin and eosin staining of middle ear sections from wild-type (C) and mutant (D) mice. The asterisk indicates accumualtion of inflammatory cells in protein-rich fluid. E and F: Hematoxylin and eosin staining of sinus sections of the wild-type (E) and mutant (F) adult mice infected with P. aeruginosa. Upon intranasal infection, mutant mice failed to clear bacteria and, at 72 hours, developed a severe exudative sinusitis characterized by abundant accumulation of inflammatory cells and bacterial debris admixed in protein-rich fluid (asterisks). G: Quantification of CFUs in the lungs of infected mice. A one-way analysis of variance test did not reveal a difference between three groups of mice (P=0.6079). Results for individual mice are shown by dots and plotted on a log scale. Lines represent the mean number for each genotype. H: Data shown are short circuit currents (lsc) or change in short circuit currents in response to amiloride, UTP, or forskolin added sequentially to the preparations. Open bars represent wild-type tracheas (n=6), and shaded bars represent mutant tracheas (n=4). Results are represented as means +/- SEM. I: MCT in the nasopharynx of adult wild-type (n=6) and mutant (n=4) mice. Data are represented as means +/- SEM. KO, knockout. Bars, 500 um.

Copyright

This image is from Voronina VA, J Cell Biol 2009 Apr 13;():, and is displayed under the terms of the Creative Commons Attribution-Noncommercial-Share Alike 3.0 Unported License. J:147413

Associated Alleles

Symbol	Name
Cby1^tm1Ktkm	chibby family member 1, beta catenin antagonist; targeted mutation 1, Ken-Ichi Takemaru

Associated Genotypes

Allelic Composition	Genetic Background
Cby1^tm1Ktkm/Cby1^tm1Ktkm	B6.129-Cby1^tm1Ktkm