Phenotype Image Detail

Image

Caption

Phenotypes of wild-type and Pkp2^tm1Wbm/Pkp2^tm1Wbm (PKP2-/-) embryos at E10.75. I and J: Light microscopy of toluidine blue-stained transverse sections of embryonic hearts. Note the reduced thickness of the atrial walls and the reduced trabeculation of the ventricle, as well as blood accumulation in the pericardial cavity of Pkp2^tm1Wbm/Pkp2^tm1Wbm hearts (arrow); ra and la, right and left atria; bc and cv, bulbus cordis (future right ventricle) and common ventricle (future left ventricle). K and L: Higher magnifications of atrial walls in wild-type and mutant hearts. In general, the atrial walls appear thinner in the mutant (L). The position of a possible small leakage site is indicated (arrowhead) in the mutant hearts (L); ed, endocardial cells; ep, epicardial cells; cm, cardiomyocytes; rb, red blood cells. Bars: 300um, I and J; 50um, K and L.

Copyright

This image is from Grossmann KS, J Cell Biol 2004 Nov 11;167(1):149-60, and is displayed under the terms of the Creative Commons Attribution-Noncommercial-Share Alike 3.0 Unported License. J:93314

Associated Alleles

Symbol	Name
Pkp2^tm1Wbm	plakophilin 2; targeted mutation 1, Walter Birchmeier

Associated Genotypes

Allelic Composition	Genetic Background
Pkp2^tm1Wbm/Pkp2^tm1Wbm	involves: C57BL/6