Phenotype Image Detail

Image

Caption

Chronic inflammation in Ptpn6^m1Btlr/Ptpn6^m1Btlr (spin) mice. A-D: Hematoxylin and eosin stained tissue sections from 2-5 month old wild-type (C57BL/6J) (A,C) and Ptpn6^m1Btlr/Ptpn6^m1Btlr (spin) (B,D) mice. The feet of mutants show a thickened epidermis with microabscesses in the epidermal (B) and dermal (D) layers accompanied by a mononuclear cell infiltrate into the dermal layer. The cellularity of the bone marrow is increased in bone cavities adjacent to the foot lesions. Sections are shown magnified 100X. E-H: The salivary glands (F) and lungs (H) of mutant mice contain hematopoietic cell infiltrates. This pathology is not evident in any wild-type mice (E,G). Salivary gland and lung sections are magnified at 100X.

Copyright

This image is from Croker BA, Proc Natl Acad Sci U S A 2008 Sep 30;105(39):15028-33. Copyright 2008 National Academy of Sciences, U.S.A. J:142845

Associated Alleles

Symbol	Name
Ptpn6^m1Btlr	protein tyrosine phosphatase, non-receptor type 6; mutation 1, Bruce Beutler

Associated Genotypes

Allelic Composition	Genetic Background
Ptpn6^m1Btlr/Ptpn6^m1Btlr	C57BL/6J-Ptpn6^m1Btlr/Mmucd