About   Help   FAQ
Phenotype Image Detail
Image
Caption Immunohistochemical staining of heart (A) and liver (B) sections from wild-type and Rb1cc1tm1.2Guan/Rb1cc1tm1.2Guan embryos at E12.5 or E14.5 with antibody against cleaved caspase-3. There is no immunostaining observed in heart or liver sections from either the mutant or wild-type embryo section at E12.5 or in the wild-type embryo at E14.5. In contrast, in the mutant embryo at E14.5, selected myocardial cells (arrows) show intense cytoplasmic and nuclear staining. Many hepatocytes also show intense cytoplasmic and nuclear staining. In the high-magnification inset, selected hepatocytes are marked with arrows.
Copyright This image is from Gan B, J Cell Biol 2006 Oct 9;175(1):121-33, and is displayed under the terms of the Creative Commons Attribution-Noncommercial-Share Alike 3.0 Unported License. J:114498
Associated
Alleles
Symbol Name
Rb1cc1tm1.2Guan RB1-inducible coiled-coil 1; targeted mutation 1.2, Jun-Lin Guan
Associated
Genotypes
Allelic Composition Genetic Background
Rb1cc1tm1.2Guan/Rb1cc1tm1.2Guan involves: 129P2/OlaHsd * C57BL/6

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
Citing These Resources
Funding Information
Warranty Disclaimer & Copyright Notice
Send questions and comments to User Support.
last database update
04/06/2021
MGI 6.16
The Jackson Laboratory