Phenotype Image Detail

Image

Caption

A and B: Scanning electron micrographs of E18.5 wild-type and Fras1^tm1Chpk/Fras1^tm1Chpk (Fras1^-/-) lungs. A: Whole lung of a wild-type embryo displaying complete septation of right lung lobes (arrowheads). B: Fused medial and caudal lobes in the right lung of mutant embryos (arrowhead). C and D: Hematoxylin and eosin staining of lung sections from E16.5 wild-type and mutant lungs. C: A wild-type control displaying the normal four-lobed pattern of the right lung. D: Mutants usually exhibit complete fusion of the medial and caudal lobes of the right lung, whereas the cranial lobe is partially separated (arrowheads). E and F: Whole lungs of wild-type and mutant embryos at E12.5. Lungs of mutant embryos (F) exhibit the same extent of epithelial branching as wild-type controls (E). Abbreviations: al, accessory lobe; cal, caudal lobe; crl, cranial lobe; e, airway epithelia; le, left lung; ml, medial lobe. Scale bar: A and B, 400 um; C and D, 10 um.

Copyright

This image is from Petrou P, J Biol Chem 2005 Mar 18;280(11):10350-6 and is displayed with the permission of the American Society for Biochemistry and Molecular Biology who owns the Copyright. Full text from JBC. J:137010

Associated Alleles

Symbol	Name
Fras1^tm1Chpk	Fraser extracellular matrix complex subunit 1; targeted mutation 1, George Chalepakis

Associated Genotypes

Allelic Composition	Genetic Background
Fras1^tm1Chpk/Fras1^tm1Chpk	involves: 129S1/Sv * 129X1/SvJ * NMRI