Phenotype Image Detail

Image

Caption

Electron microscopy of the distal tubular epithelial cells of Hsd11b2^tm1Yko/Hsd11b2^tm1Yko (A) and wild-type mice (B). Distal tubular epithelial cells from mutant mice show an increase in size. The subnuclear, or basal, pole is expanded with apical displacement of the nucleus. The number of mitochondria (m) in each distal tubular cell is increased, although the mitochondria remain located at the expanded basal pole (bm, basal membrane). Occasional membrane-enclosed vacuoles (v) are seen in the cytoplasm of the distal tubular epithelial cells from the mutant mice. x3,800.

Copyright

This image is from Kotelevtsev Y, J Clin Invest 1999 Mar;103(5):683-9 and is displayed with the permission of the American Society for Clinical Investigation who owns the Copyright. J:53391

Associated Alleles

Symbol	Name
Hsd11b2^tm1Yko	hydroxysteroid 11-beta dehydrogenase 2; targeted mutation 1, Yuri V Kotelevtsev

Associated Genotypes

Allelic Composition	Genetic Background
Hsd11b2^tm1Yko/Hsd11b2^tm1Yko	involves: 129P2/OlaHsd * MF1