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Caption Electron microscopy of the distal tubular epithelial cells of Hsd11b2tm1Yko/Hsd11b2tm1Yko (A) and wild-type mice (B). Distal tubular epithelial cells from mutant mice show an increase in size. The subnuclear, or basal, pole is expanded with apical displacement of the nucleus. The number of mitochondria (m) in each distal tubular cell is increased, although the mitochondria remain located at the expanded basal pole (bm, basal membrane). Occasional membrane-enclosed vacuoles (v) are seen in the cytoplasm of the distal tubular epithelial cells from the mutant mice. x3,800.
Copyright This image is from Kotelevtsev Y, J Clin Invest 1999 Mar;103(5):683-9 and is displayed with the permission of the American Society for Clinical Investigation who owns the Copyright. J:53391
Symbol Name
Hsd11b2tm1Yko hydroxysteroid 11-beta dehydrogenase 2; targeted mutation 1, Yuri V Kotelevtsev
Allelic Composition Genetic Background
Hsd11b2tm1Yko/Hsd11b2tm1Yko involves: 129P2/OlaHsd * MF1

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