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Caption Skin comparison of newborn Slc27a4tm1Wsr/Slc27a4tm1Wsr and wild-type littermates. A: Neonatal dorsal skin stained with hematoxylin and eosin. In comparison with wild-type (Fatp4 +/+) epidermis, Slc27a4tm1Wsr/Slc27a4tm1Wsr (Fatp4 -/-) epidermis exhibits an increased number of cell layers in the stratum spinosum and the basal layer, significantly smaller granula in the stratum granulosum, and a compact, thickened stratum corneum. Bars, 50 um. B: Neonatal snout skin stained with Masson's trichrome. In comparison with wild-type dermis, the dermis of mutant mice appears condensed with more compact collagen fibers. Bars, 50 um. C: Ultrastructural analysis of epidermis of mutant mice and wild-type littermates (osmium tetroxide fixation). In comparison with control epidermis, the epidermis of mutant mice is characterized by significantly smaller, often irregularly shaped granules (arrow) in the stratum granulosum. Bars, 5 um. (D, top) In wild-type mice, immunostaining using Slc27a4 antiserum shows prominent staining along the cell-cell borders (arrows) in upper layers of the stratum spinosum and in the stratum granulosum subjacent to the stratum corneum (sc), besides a very faint and sparse staining in the lower layers of the stratum spinosum. The inset shows a higher magnification. In mutant mice, these structures appear negative for such a staining pattern. Only a very faint staining is detectable in cells of the stratum basale (sb) of both wild-type and mutant mice. (Bottom) Phase-contrast images of the same sections. Blue: DAPI nuclear staining. Bars, 50 um.
Copyright This image is from Herrmann T, J Cell Biol 2003 Jun 23;161(6):1105-15, and is displayed under the terms of the Creative Commons Attribution-Noncommercial-Share Alike 3.0 Unported License. J:84096
Symbol Name
Slc27a4tm1Wsr solute carrier family 27 (fatty acid transporter), member 4; targeted mutation 1, Wolfgang Stremmel
Allelic Composition Genetic Background
Slc27a4tm1Wsr/Slc27a4tm1Wsr involves: 129P2/OlaHsd * C57BL/6

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