Phenotype Image Detail

Image

Caption

Maf^tm1Mym/Maf^tm1Mym newborns lack a normal lens structure (A, arrow; B shows wild-type). Maf deficiency prevents elongation of posterior lens fiber cells in mutant (C) but not in wild-type (D) mice. A normal lens structure is not visible in the E16.5 mutant embryo (E, arrow), whereas the wild-type E16.5 embryo has a visible lens structure (F). In the E16.5 mutant embryo (G), unlike its wild-type littermate (H), the lens fiber cells are not elongated, and consequently, the lens cavity is empty. Sections were stained with hematoxylin and eosin. Original magnification of the sections are x200 (C,G and H) or x100 (D).

Copyright

This image is from Kawauchi S, J Biol Chem 1999 Jul 2;274(27):19254-60 and is displayed with the permission of the American Society for Biochemistry and Molecular Biology who owns the Copyright. Full text from JBC. J:56095

Associated Alleles

Symbol	Name
Maf^tm1Mym	MAF bZIP transcription factor; targeted mutation 1, Masayuki Yamamoto

Associated Genotypes

Allelic Composition	Genetic Background
Maf^tm1Mym/Maf^tm1Mym	either: (involves: 129/Sv * C57BL/6J) or (involves: 129/Sv * ICR)