Phenotype Image Detail

Image

Caption

Nonlymphoid phenotypes in Ada^tm1Mw/Ada^tm1Mw Tg(PLADA)4118Rkmb/0 mice. Lung tissues from control (panel A) and Ada^tm1Mw/Ada^tm1Mw Tg(PLADA)4118Rkmb/0 mice (panel B) were collected at postnatal day 15, and sections were stained with hematoxylin and eosin. br, bronchiole; a, alveoli; e, bronchiolar epithelium; *, immune cells in lumen of bronchiole; large arrow, hypertrophied smooth muscle. Postnatal day 15 rib cages from control (panel C) and mutant (panel D) mice were stained with alyzarin red and azure blue to monitor bone (red) and cartilage (blue) morphology. White arrows point to costochondral junctions. * in panel D denotes severe curvature of ribs seen in mutant mice. Hematoxylin and eosin stained sections through control (panel E) and mutant (panel F) kidneys. g, glomerulus; t, convoluted tubules; * and arrows in panel F denote areas of increased blood content in mutant kidneys. Scale bar in F=100 um for A,B,E and F.

Copyright

This image is from Blackburn MR, J Biol Chem 1998 Feb 27;273(9):5093-100 and is displayed with the permission of the American Society for Biochemistry and Molecular Biology who owns the Copyright. Full text from JBC. J:73418

Associated Alleles

Symbol	Name
Ada^tm1Mw	adenosine deaminase; targeted mutation 1, Maki Wakamiya
Tg(PLADA)4118Rkmb	transgene insertion 4118, Michael R Blackburn

Associated Genotypes

Allelic Composition	Genetic Background
Ada^tm1Mw/Ada^tm1Mw Tg(PLADA)4118Rkmb/0	involves: 129S7/SvEvBrd * C57BL/6