Phenotype Image Detail

Image

Caption

Electron micrograph of hepatocytes from the liver of an 8 month old Acox1^tm1Jkr/Acox1^tm1Jkr mouse (A), compared with that of a wild-type mouse (B). Liver was processed for the cytochemical localization of catalase using 3,3'-diaminobenzidine medium. Note the presence of numerous catalase positive peroxisomes (P) with urate oxidase crystalloid inclusions in the mutant mouse hepatocytes. In contrast, hepatocytes in wild-type mice (A) reveal the presence of a few peroxisomes (P).

Copyright

This image is from Fan CY, J Biol Chem 1998 Jun 19;273(25):15639-45 and is displayed with the permission of the American Society for Biochemistry and Molecular Biology who owns the Copyright. Full text from JBC. J:48180

Associated Alleles

Symbol	Name
Acox1^tm1Jkr	acyl-Coenzyme A oxidase 1, palmitoyl; targeted mutation 1, Janardan K Reddy

Associated Genotypes

Allelic Composition	Genetic Background
Acox1^tm1Jkr/Acox1^tm1Jkr	involves: 129P2/OlaHsd * C57BL/6J