About   Help   FAQ
Phenotype Image Detail
Image
Caption Dyslamination in Foxc1hith/Foxc1hith mice. A and B: Tbr1 staining of P10 brains shows labeling of layers 2/3, 5, and 6 in control (Foxc1+/) and Foxc1hith/Foxc1hith (hith/hith) brains. The mutant brains are montages generated by merging two images of both brain hemispheres. In mutant brains Tbr1+ cells form heterotopic clusters in the marginal zone (blue arrows in Insets) and reveal significant disorganization of cortical layers (black arrows). C-F: Ctip2 staining labels cells in layers 5 and 6, and ER81 labels cells in layer 5, and both show significant laminar disorganization in mutant brains (black arrows); however, note that there are no Ctip2- or ER81-stained cells in the marginal zone.
Copyright This image is from Zarbalis K, Proc Natl Acad Sci U S A 2007 Aug 28;104(35):14002-7. Copyright 2007 National Academy of Sciences, U.S.A. J:136459
Associated
Alleles
Symbol Name
Foxc1hith forkhead box C1; hole-in-the-head
Associated
Genotypes
Allelic Composition Genetic Background
Foxc1hith/Foxc1hith involves: C57BL/6J * FVB/N

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
Warranty Disclaimer & Copyright Notice
Send questions and comments to User Support.
last database update
08/19/2014
MGI 5.19
The Jackson Laboratory