Phenotype Image Detail

Image

Caption

A-D: Electron micrographs of sections from E12 brains. A: A wild-type (T-syn^+/+) capillary has a uniform lumen and a pericyte that is intimately associated with the endothelial cell. B-D: C1galt1^tm1Rpmc/C1galt1^tm1Rpmc capillaries have distended or distorted lumens with attenuated endothelial cell processes. The upper pericyte in C is in close contact with an endothelial cell, but other pericytes are partially or completely separated from the endothelial cells. Large empty spaces (asterisks) surround the capillaries. Both wild-type and mutant capillaries have normal interendothelial cell junctions (arrowheads). Ec, endothelial cell; Pc, pericyte. E: Sections of capillaries were scored for pericytes closely attached to endothelial cells and for distortions in endothelial cell shape. Bars, 2 um.

Copyright

This image is from Xia L, J Cell Biol 2004 Feb 2;164(3):451-9, and is displayed under the terms of the Creative Commons Attribution-Noncommercial-Share Alike 3.0 Unported License. J:96775

Associated Alleles

Symbol	Name
C1galt1^tm1Rpmc	core 1 synthase, glycoprotein-N-acetylgalactosamine 3-beta-galactosyltransferase, 1; targeted mutation 1, Roger P McEver

Associated Genotypes

Allelic Composition	Genetic Background
C1galt1^tm1Rpmc/C1galt1^tm1Rpmc	involves: 129S1/Sv * C57BL/6J