Phenotype Image Detail

Image

Caption

Development of the appendicular skeleton in Gja1^tm1Kdr/Gja1^tm1Kdr embryos. Front limbs at E14.5 (A), clavicle at birth (B) and front limbs at birth (C and D) were stained with alizarin red/alcian blue. Note, the delayed mineralization of the scapula and the long limb bones (humerus, radius, and cubitus) in the Gja1^tm1Kdr/Gja1^tm1Kdr (Cx43-/-) embryos at (A) E14.5 compared with (C and D) normal birth. Also, note the lack of both intramembranous and endochondral ossification of the clavicle, present only as a small cartilaginous template in the (A, arrows) mutant mice at E14.5. However, the clavicles appeared normal at (B) birth. E: Longitudinal sections of safranin O/fast green-stained femurs of wild-type (WT) and mutant neonates. The size and morphology of the growth plate is apparently normal, as is the primary spongiosa in the homozygous mutant bone.

Copyright

This image is from Lecanda F, J Cell Biol 2000 Nov 13;151(4):931-44, and is displayed under the terms of the Creative Commons Attribution-Noncommercial-Share Alike 3.0 Unported License. J:65866

Associated Alleles

Symbol	Name
Gja1^tm1Kdr	gap junction protein, alpha 1; targeted mutation 1, Gerald M Kidder

Associated Genotypes

Allelic Composition	Genetic Background
Gja1^tm1Kdr/Gja1^tm1Kdr	involves: 129S1/Sv * 129X1/SvJ * C57BL