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Phenotype Image Detail
Image
Caption Development of the appendicular skeleton in Gja1tm1Kdr/Gja1tm1Kdr embryos. Front limbs at E14.5 (A), clavicle at birth (B) and front limbs at birth (C and D) were stained with alizarin red/alcian blue. Note, the delayed mineralization of the scapula and the long limb bones (humerus, radius, and cubitus) in the Gja1tm1Kdr/Gja1tm1Kdr (Cx43-/-) embryos at (A) E14.5 compared with (C and D) normal birth. Also, note the lack of both intramembranous and endochondral ossification of the clavicle, present only as a small cartilaginous template in the (A, arrows) mutant mice at E14.5. However, the clavicles appeared normal at (B) birth. E: Longitudinal sections of safranin O/fast green-stained femurs of wild-type (WT) and mutant neonates. The size and morphology of the growth plate is apparently normal, as is the primary spongiosa in the homozygous mutant bone.
Copyright This image is from Lecanda F, J Cell Biol 2000 Nov 13;151(4):931-44, and is displayed under the terms of the Creative Commons Attribution-Noncommercial-Share Alike 3.0 Unported License. J:65866
Associated
Alleles
Symbol Name
Gja1tm1Kdr gap junction protein, alpha 1; targeted mutation 1, Gerald M Kidder
Associated
Genotypes
Allelic Composition Genetic Background
Gja1tm1Kdr/Gja1tm1Kdr involves: 129S1/Sv * 129X1/SvJ * C57BL

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
10/08/2019
MGI 6.14
The Jackson Laboratory