Phenotype Image Detail

Image

Caption

Histological analysis of tissues from Npr1^tm1Mae/Npr1^tm1Mae male mice and wild type controls. A-E: Heart tissues from euthanized mice stained with Masson's trichrome. Hearts were fixed without diastole arrest and with no intracardiac pressure, consequently the in vivo dilatation of the mutant hearts was not preserved. A: x9 and C: x175 magnification of transverse sections of the heart from a 3.5 month old wild type male. B: x9 and D: x175 magnification of sections from a 3.5 month old mutant male. Fibrotic regions stain blue. E: x175 magnification of a section of a 4 month old mutant male showing dying myocytes (blue). F: x45 magnification of the aortic dissection from a deceased 3.5 month old mutant male, stained with trichrome-elastin stain to show elastic and connective tissue. The platelet-fibrin strands in the clot in the lower left quadrant show that some bleeding had occurred before death of the mouse.

Copyright

This image is from Oliver PM, Proc Natl Acad Sci U S A 1997 Dec 23;94(26):14730-5. Copyright 1997 National Academy of Sciences, U.S.A. J:74420

Associated Alleles

Symbol	Name
Npr1^tm1Mae	natriuretic peptide receptor 1; targeted mutation 1, Nobuyo Maeda

Associated Genotypes

Allelic Composition	Genetic Background
Npr1^tm1Mae/Npr1^tm1Mae	involves: 129P2/OlaHsd * C57BL/6