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Phenotype Image Detail
Image
Caption Histological analysis of tissues from Npr1tm1Mae/Npr1tm1Mae male mice and wild type controls. A-E: Heart tissues from euthanized mice stained with Masson's trichrome. Hearts were fixed without diastole arrest and with no intracardiac pressure, consequently the in vivo dilatation of the mutant hearts was not preserved. A: x9 and C: x175 magnification of transverse sections of the heart from a 3.5 month old wild type male. B: x9 and D: x175 magnification of sections from a 3.5 month old mutant male. Fibrotic regions stain blue. E: x175 magnification of a section of a 4 month old mutant male showing dying myocytes (blue). F: x45 magnification of the aortic dissection from a deceased 3.5 month old mutant male, stained with trichrome-elastin stain to show elastic and connective tissue. The platelet-fibrin strands in the clot in the lower left quadrant show that some bleeding had occurred before death of the mouse.
Copyright This image is from Oliver PM, Proc Natl Acad Sci U S A 1997 Dec 23;94(26):14730-5. Copyright 1997 National Academy of Sciences, U.S.A. J:74420
Associated
Alleles
Symbol Name
Npr1tm1Mae natriuretic peptide receptor 1; targeted mutation 1, Nobuyo Maeda
Associated
Genotypes
Allelic Composition Genetic Background
Npr1tm1Mae/Npr1tm1Mae involves: 129P2/OlaHsd * C57BL/6

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
08/13/2019
MGI 6.14
The Jackson Laboratory