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Phenotype Image Detail
Caption A: Omphalocele in Rock1tm1Sna/Rock1tm1Sna embryos. Wild type and mutant embryos at 18.5 dpc are shown. Severe, moderate, and mild forms of omphalocele are apparent in the mutant mice shown in the center left, center right and right panels, respectively. Arrowheads indicate the epidermal ridge in the wild type embryo. B: Hematoxylin and eosin staining of sagittal sections through the umbilical region of wild type (top) and mutant (bottom) embryos at 15.5 (left) and 16.5 (right) dpc. Boxes indicate the region of the ectodermal-amnion transition. Arrows indicate the epidermal ridge. Bar, 1mm. C: Higher magnification images of the boxed regions in B. Arrows indicate the epidermal ridge in the wild type embryo. Bar, 200um. D: Staining of the epidermal ridge. Sections of the epidermal ridge in wild type (top) and mutant (bottom) embryos at 16.5 dpc were stained with an antibody to phosphorylated MLC (green, arrowheads) and phalloidin (red, arrows) in the left panels, and with phalloidin (red) and an antibody to keratin 5 (green) in the right panel. Bars, 50um.
Copyright This image is from Shimizu Y, J Cell Biol 2005 Mar 14;168(6):941-53, and is displayed under the terms of the Creative Commons Attribution-Noncommercial-Share Alike 3.0 Unported License. J:98250
Symbol Name
Rock1tm1Sna Rho-associated coiled-coil containing protein kinase 1; targeted mutation 1, Shuh Narumiya
Allelic Composition Genetic Background
Rock1tm1Sna/Rock1tm1Sna B6N.129X1-Rock1tm1Sna

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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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