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Phenotype Image Detail
Image
Caption A: Calcein double labeling in 6 month old wild type and Lrp5tm1Kry/Lrp5tm1Kry mice. The distance between the two labels (double-headed arrows) represents the matrix apposition rate (MAR) which is decreased in mutant mice. As a result, the bone formation rate (BFR) is significantly lower in mutant mice. B: Decreased osteoblast number per bone area in the primary (left) and secondary (right) spongiosa of mutant mice compared with wild type. C: Delayed mineralization in primary mutant osteoblast cultures compared with wild type cultures at day 10 of mineralization. D: Normal tibial growth plate in 2 month old mutant mice (von Kossa stain). Asterisks indicate a statistically significant difference between two groups of mice (P<0.05). Error bars represent SD.
Copyright This image is from Kato M, J Cell Biol 2002 Apr 15;157(2):303-14, and is displayed under the terms of the Creative Commons Attribution-Noncommercial-Share Alike 3.0 Unported License. J:75973
Associated
Alleles
Symbol Name
Lrp5tm1Kry low density lipoprotein receptor-related protein 5; targeted mutation 1, Gerard Karsenty
Associated
Genotypes
Allelic Composition Genetic Background
Lrp5tm1Kry/Lrp5tm1Kry either: (involves: 129S1/Sv * 129X1/SvJ) or (involves: 129S1/Sv * 129X1/SvJ * C57BL/6J)

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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
09/02/2014
MGI 5.19
The Jackson Laboratory