Phenotype Image Detail

Image

Caption

A: The lateral view of the incisor teeth from Amelx^tm1Msnd/Amelx^tm1Msnd (deltaA/deltaA), age matched wild type (Wt/Wt) and Amelx^tm2Msnd/Amelx^tm2Msnd (deltaB/deltaB) mice depict the differences in the enamel thickness for the mutant mice compared to the age matched wild type. The dotted line is traced at the optical junction of dentine to enamel. B,C and D: Panels 1 shows the facial view of the incisor teeth from the Amelx^tm1Msnd/Amelx^tm1Msnd (B1), age matched wild type (C1) and Amelx^tm1Msnd/Amelx^tm1Msnd (D1) depicting enamel fractures occuring at the incisal-edge in the mutant mice compared to the age-matched wild type. Panels 2 shows an occlusal view of the molar teeth from the Amelx^tm1Msnd/Amelx^tm1Msnd (B2) mice, age matched wild type (C2) and Amelx^tm2Msnd/Amelx^tm2Msnd (D2) mice depicting enamel abrasion from the molars of the mutant mice compared to age-matched wild type. E: Two magnifications of fractured enamel from a Amelx^tm1Msnd/Amelx⁺ female mouse showing chimeric distribution of wild type enamel adjacent to enamel created from the deltaA-engineered replacement amelogenin. The dotted line indicates the boundary between wild type (canonical) and altered rod enamel architecture.

Copyright

This image is from Zhu D, J Biol Chem 2006 Jul 28;281(30):21173-82 and is displayed with the permission of the American Society for Biochemistry and Molecular Biology who owns the Copyright. Full text from JBC. J:116448

Associated Alleles

Symbol	Name
Amelx^tm1Msnd	amelogenin, X-linked; targeted mutation 1, Malcolm L Snead
Amelx^tm2Msnd	amelogenin, X-linked; targeted mutation 2, Malcolm L Snead

Associated Genotypes

Allelic Composition	Genetic Background
Amelx^tm1Msnd/Amelx^tm1Msnd	involves: 129X1/SvJ
Amelx^tm2Msnd/Amelx^tm2Msnd	involves: 129X1/SvJ