Phenotype Image Detail

Image

Caption

Scanning electron micrographs taken from the apex (A,E), the middle (B,F), and the base (C,G) of Myo7a^Hdb/Myo7a⁺ (Hdb/+) and Myo7a^Hdb/Myo7a⁺ Myo7a^4626SB/Myo7a⁺ (Hdb/Myo7a^4626SB) from a complementation test between the mutants. Inner hair cell (IHC) fusion was evident predominantly in the apical coil of the compound heterozygote cochleae (E); however this was not as frequent as seen in the homozygous Hdb cochlea. Outer hair cell (OHC) stereocilia bundles formed into irregular V and O shapes in the apical (E) and the middle (F) coils. IHC stereocilia bundles in the middle (F) and basal (G) coils appeared comparable to control (B and C), respectively) with very few fused bundles. The Myo7a^Hdb/Myo7a⁺ Myo7a^4626SB/Myo7a⁺ hair cell phenotype did not resemble the Myo7a^sh1/Myo7a^sh1 (sh/sh) phenotype (compare H and E apical coil). P3 Myo7a^sh1/Myo7a^sh1 samples are shown in this example rather than adults, because hair cells degenerate rapidly making comparison with the Myo7a^Hdb phenotype difficult (D, Myo7a^sh1/Myo7a⁺ (+/sh) littermate control). Scale bar, 10um.

Copyright

This image is from Rhodes CR, Mamm Genome 2004 Sep;15(9):686-97 and is displayed with the permission of Springer Science + Business Media, Inc., New York who owns the copyright. J:93998

Associated Alleles

Symbol	Name
Myo7a^4626SB	myosin VIIA; shaker 4626SB
Myo7a^Hdb	myosin VIIA; headbanger
Myo7a^sh1	myosin VIIA; shaker 1

Associated Genotypes

Allelic Composition	Genetic Background
Myo7a^sh1/Myo7a^sh1	involves: BALB
Myo7a^Hdb/Myo7a^+	C3HeB/FeJ-Myo7a^Hdb/Ieg
Myo7a^Hdb/Myo7a^4626SB	involves: BALB/c * 47BS/Rl * C3HeB/FeJ * CBA/Ca