Phenotype Image Detail

Image

Caption

A: Reduced size of E14.5 Akt1^tm1Hem/Akt1^tm1Hem embryos and their placentae. Embryos and their placentae were dissected from Akt1^tm1Hem/Akt1⁺ intercrosses at E14.5. After weighing the embryos and placentae, tissues from the embryos or yolk sac were dissected and used for DNA isolation and genotyping by PCR. Data from wild-type and homozygous mutant embryos and placentae were collected for statistical analysis as shown on the left (*, p<0.01). The right picture shows the smaller size of mutant embryo and its placenta compared with those of wild type at this gestational age. B: Similar results were obtained at E16.5 (left, weight of wild type and mutant embryos and placentae; *, p<0.01; right, picutre of wild type and mutant embryos and placentae at this age).

Copyright

This image is from Yang ZZ, J Biol Chem 2003 Aug 22;278(34):32124-31 and is displayed with the permission of the American Society for Biochemistry and Molecular Biology who owns the Copyright. Full text from JBC. J:85181

Associated Alleles

Symbol	Name
Akt1^tm1Hem	thymoma viral proto-oncogene 1; targeted mutation 1, Brian A Hemmings

Associated Genotypes

Allelic Composition	Genetic Background
Akt1^tm1Hem/Akt1^tm1Hem	involves: 129P2/OlaHsd * C57BL/6