Phenotype Image Detail

Image

Caption

(a) Cervical, axillary, inguinal, and mesenteric lymph nodes were removed from a 2-month-old wild-type (WT) and Gba1^tm1Rlp/Gba1^tm1Rlp (L444P/L444P) mice. The lymph nodes of mutant mice (b) showed follicular hyperplasia and dilated parafollicular zones compared with the lymph nodes of control mice (c). Immunostaining for kappa light chain showed large numbers of positive cells in the lymph nodes of the mutant mice (d) compared with wild-type mice (e). Arrows point out a few of the positive cells. (f) Plasmacytosis in the cervical lymph node of a 9-month-old mutant mouse. Arrows point out a few of the abundant large plasma cells. Bars = 50um. (g) Left panel: IL-1beta mRNA expression in the cervical lymph nodes of mutant and wild type mice. Results are means +/- SEM for six mice. *P < 0.05. Right panel: Serum IgG levels in mutant and wild type mice. Results are means +/- SEM for five mice.

Copyright

This image is from Mizukami H, J Clin Invest 2002 May;109(9):1215-21 and is displayed with the permission of the American Society for Clinical Investigation who owns the Copyright. J:76409

Associated Alleles

Symbol	Name
Gba1^tm1Rlp	glucosylceramidase beta 1; targeted mutation 1, Richard L Proia

Associated Genotypes

Allelic Composition	Genetic Background
Gba1^tm1Rlp/Gba1^tm1Rlp	involves: 129S4/SvJae * C57BL/6