Phenotype Image Detail

Image

Caption

Representative proximal tibia sections from control (a), Igf1^tm1Dlr/Igf1^tm1Dlr (LID, b), Igfals^tm1Yrb/Igfals^tm1Yrb (ALSKO, c) and Igf1^tm1Dlr/Igf1^tm1Dlr Igfals^tm1Yrb/Igfals^tm1Yrb Tg(Alb1-cre)1Dlr/? (LID+ALSKO, d) mice at postnatal day 28. Sections were visualized with the Masson trichrome technique, which stains nuclei black, stains collagen blue, and stains calcified matrix red. In Igf1^tm1Dlr/Igf1^tm1Dlr Igfals^tm1Yrb/Igfals^tm1Yrb Tg(Alb1-cre)1Dlr/? mice, the total height of the growth plate is significantly reduced (bar, 200um). Inserts (bar=50um) show the germinal zone (GZ), proliferating zone (PZ), and hypertrophic zone (HZ) of chondrocytes.

Copyright

This image is from Yakar S, J Clin Invest 2002 Sep;110(6):771-81 and is displayed with the permission of the American Society for Clinical Investigation who owns the Copyright. J:79109

Associated Alleles

Symbol	Name
Igf1^tm1Dlr	insulin-like growth factor 1; targeted mutation 1, Derek LeRoith
Igfals^tm1Yrb	insulin-like growth factor binding protein, acid labile subunit; targeted mutation 1, Yves R Boisclair
Tg(Alb1-cre)1Dlr	transgene insertion 1, Derek LeRoith

Associated Genotypes

Allelic Composition	Genetic Background
Igf1^tm1Dlr/Igf1^tm1Dlr Igfals^tm1Yrb/Igfals^tm1Yrb Tg(Alb1-cre)1Dlr/?	involves: 129S4/SvJae * BALB/c * C57BL/6 * FVB/N