Phenotype Image Detail

Image

Caption

Sagittal sections of 12.5 dpc wild type (B) and Sox2^tm1Rlb/Sox2⁺ (C) embryos showing bifurcation of the pouch in the mutant embryo. (D and E) Pituitary transverse sections of 5-week-old wild-type (D) and heterozygous mice (E). Note the presence of an extra cleft in the heterozygous pituitary (arrow). HYP, presumptive hypothalamus; RP, Rathke's pouch. Scale bars: 0.1 mm.

Copyright

This image is from Kelberman D, J Clin Invest 2006 Sep;116(9):2442-55 and is displayed with the permission of the American Society for Clinical Investigation who owns the Copyright. J:114458

Associated Alleles

Symbol	Name
Sox2^tm1Rlb	SRY (sex determining region Y)-box 2; targeted mutation 1, Robin Lovell-Badge

Associated Genotypes

Allelic Composition	Genetic Background
Sox2^tm1Rlb/Sox2^+	involves: 129S/SvEv * MF1