Phenotype Image Detail

Image

Caption

A: Dorsal view of x-ray images of skulls of P21 day old Fgfr3^tm3.1Cxd/Fgfr3^tm3.1Cxd (369/369), Fgfr3^tm3.1Cxd/Fgfr3⁺ (369/+) and wild type (WT) mice. B: Cranial base of wild type, and homozygous mutant (C) mice. Arrows point to synchondroses: basooccipital (oc), basosphenoid (ba) and presphenoid (pr). Notice the absence of synchondroses in homozygous mutant mice (arrows in c). D: Hematoxylin and eosin stained image of a wild type synchondrosis, which exhibits typical growth plate structures, including proliferating and maturing chondrocytes [positive for Fgfr3 (E)], and hypertrophic chondrocytes [positive for collagen type X (F)]. G: Hematoxylin and eosin stained image of corresponding region of a homozygous mutant sychondrosis, which had completely turned to bone. H-J: P6 synchondroses (arrows) of homozygous (H), heterozygous (I), and wild type (J) mice. The homozygous synchondrosis was much thinner that the wild type synchondrosis and was in a process of resolving, while the heterozygous synchondrosis (I) exhibited an intermediate phenotype between those of homozygous and wild type.

Copyright

This image is from Chen L, J Clin Invest 1999 Dec;104(11):1517-25 and is displayed with the permission of the American Society for Clinical Investigation who owns the Copyright. J:69849

Associated Alleles

Symbol	Name
Fgfr3^tm3.1Cxd	fibroblast growth factor receptor 3; targeted mutation 3.1, Chu-Xia Deng

Associated Genotypes

Allelic Composition	Genetic Background
Fgfr3^tm3.1Cxd/Fgfr3^tm3.1Cxd	involves: 129S6/SvEvTac
Fgfr3^tm3.1Cxd/Fgfr3^+	involves: 129S6/SvEvTac