Phenotype Image Detail

Image

Caption

A: Calvarias and clavicles of Gsk3b^tm1Jrw/Gsk3b⁺, Runx2^tm1Kish/Runx2⁺, and Gsk3b^tm1Jrw/Gsk3b⁺ Runx2^tm1Kish/Runx2⁺ neonates (0-day) stained with Alizarian red and Alcian blue (bars, 3mm for calvaria and 0.5mm for clavicle). B: Quantitative analyses using the NIH image of the anterior fortanelle area and the clavicle length of the four genotypes. For (B), data are mean (bars)+/-SEM (error bars) of the relative amount compared to Runx2^tm1Kish/Runx2⁺ of 6 mice per group.

Copyright

This image is from Kugimiya F, PLoS ONE 2007;2(9):e837, an open-access article distributed under the terms of the Creative Commons Attribution License. J:129364

Associated Alleles

Symbol	Name
Gsk3b^tm1Jrw	glycogen synthase kinase 3 beta; targeted mutation 1, James R Woodgett
Runx2^tm1Kish	runt related transcription factor 2; targeted mutation 1, Tadamitsu Kishimoto

Associated Genotypes

Allelic Composition	Genetic Background
Runx2^tm1Kish/Runx2^+	involves: 129P2/OlaHsd * C57BL/6
Gsk3b^tm1Jrw/Gsk3b^+	involves: 129 * C57BL/6
Gsk3b^tm1Jrw/Gsk3b^+ Runx2^tm1Kish/Runx2^+	involves: 129 * 129P2/OlaHsd * C57BL/6