Phenotype Image Detail

Image

Caption

A: Two inferior venous structures are seen in Dnah5^hlb612/Dnah5^hlb612 mice. B: 3D reconstruction shows opening of dual cava (arrowheads) into the base of the atria, with the right inferior vena cava (IVC) (RIVC) most anterior. The morpholgic right ventricle (mRV) is positioned superiorly and the morphologic left ventricle (mLV) inferiorly. C: 3D reconstriction looking posteriorly at the left and right IVCs connecting to the base of the 2 morphologic right atria suggests right atrial isomerism. The arrowheads highlight the border of the atrioventricular (AV) canal, from which blood empties into both the mLV and mRV. Side-by-side outflows are also present with the aorta anterior and on the left and the pulmonary artery (PA) on the right. D: Original 2D image looking anteriorly at the 2 atria. Note the presence of duplicated IVC entering into the base of both morphologic right atria. RA, right atrium. Scale bars: 500um.

Copyright

This image is from Tan SY, J Clin Invest 2007 Dec;117(12):3742-52 and is displayed with the permission of the American Society for Clinical Investigation who owns the Copyright. J:130755

Associated Alleles

Symbol	Name
Dnah5^hlb612	dynein, axonemal, heavy chain 5; heart, lung and blood 612

Associated Genotypes

Allelic Composition	Genetic Background
Dnah5^hlb612/Dnah5^hlb612	involves: C57BL/6J