Phenotype Image Detail

Image

Caption

A and B: Outflow tract defects. (A) Posterior view of heart exhibiting dextrocardia with tetralogy of Fallot (TOF). The aorta (Ao) overrides the ventricular septal defect (VSD) and is continuous with both the left-sided morphologic right ventricle (mRV) and the right-sided morphologic left ventricle (mLV). The pulmonary artery (PA) is narrower than the Ao. The mitral valve (MV) is continuous with the aortic valve and opens into the mLV. (B) Posterior view of heart with levocardia and double outlet right ventricle (DORV). Both the PA and Ao open into the right-sided mRV. C and D: Atrial isomerism and common atrioventricular (AV) canal. (C) Frontal view showing left atrial isomerism with both superior vena cavas (SVCs) entering the common atrium (CA) laterally. Rather than the right SVC entering the roof of the right atrium and the left SVC entering the right atrium via the coronary sinus, teh SVCs return symmetrically to the sides of the CA, which serves as both the right atrium and the coronary sinus. Two hepatic veins (HVs) also return directly via midline to the common atrium inferiorly. (D) Resectioned 2D transverse slice from 3D reconstruction, showing a common AV canal (AVC) with single AV leaflet. Note the symmetry of the 2 SVCs. Scale bars: 200um.

Copyright

This image is from Tan SY, J Clin Invest 2007 Dec;117(12):3742-52 and is displayed with the permission of the American Society for Clinical Investigation who owns the Copyright. J:130755

Associated Alleles

Symbol	Name
Dnah5^hlb612	dynein, axonemal, heavy chain 5; heart, lung and blood 612

Associated Genotypes

Allelic Composition	Genetic Background
Dnah5^hlb612/Dnah5^hlb612	involves: C57BL/6J