Phenotype Image Detail

Image

Caption

Bone and cartilaginous skull tissue anatomy of wild type (+/+) and Eya4^tm1Jse/Eya4^tm1Jse (-/-) mice. Top (A) and lateral (B) skull views demonstrated no craniofacial abnormalities in mutant or wild type mice (n=3 for each genotype), but ventral view (C) showed abnormal fusion of palatal bones (dashed box) in mutant mice. (D) Higher magnification of palatal bones (C, dashed box) and schematic detailing morphologic abnormalities. Note wide seperation between flanking palatal bones (incomplete fusion) in mutant mouse skulls. Pt, pterygoid bone; m, maxillary shelves; P, palate bone. Scale bar: 1mm.

Copyright

This image is from Depreux FF, J Clin Invest 2008 Feb;118(2):651-8 and is displayed with the permission of the American Society for Clinical Investigation who owns the Copyright. J:131873

Associated Alleles

Symbol	Name
Eya4^tm1Jse	EYA transcriptional coactivator and phosphatase 4; targeted mutation 1, Jonathan G Seidman

Associated Genotypes

Allelic Composition	Genetic Background
Eya4^tm1Jse/Eya4^tm1Jse	involves: 129S6/SvEvTac * CBA/J