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Phenotype Image Detail
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Caption A: Percentage of fragmented unfertilized oocytes collected in the ampullae of females at different ages after exogenous hormonal stimulation. Total number of oocytes analyzed is indicated above the columns (open columns, wild type; black columns Gpr3tm1Cled/Gpr3tm1Cled, oocytes). Whereas both genotypes produced progressively more fragmented oocytes with age (P<0.001), at all ages, homozygous mutant mice produced more fragmented oocytes than wild type (P<0.001). B: Non fertilized mutant oocytes observed in light microscopy by using Nomarski optics at time of harvest in the ampullae of superovulated females. Normally shaped unfertilized oocytes with or without polar body, fragmented oocytes, and oocytes exhibiting cytoplasmic condensation are observed. Scale Bar, 40um. C: Histology sections of mutant fragmented oocytes observed in follicles (A and B) and oviducts (C) after stimulation by human chorionic gonadotropin. Scale Bar, A-C 20um; B, 10um.
Copyright This image is from Ledent C, Proc Natl Acad Sci U S A 2005 Jun 21;102(25):8922-6. Copyright 2005 National Academy of Sciences, U.S.A. J:105182
Associated
Alleles
Symbol Name
Gpr3tm1Cled G-protein coupled receptor 3; targeted mutation 1, Catherine Ledent
Associated
Genotypes
Allelic Composition Genetic Background
Gpr3tm1Cled/Gpr3tm1Cled either: B6.129-Gpr3tm1Cled or (involves: 129S1/Sv * 129X1/SvJ * CD-1)

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last database update
07/23/2014
MGI 5.19
The Jackson Laboratory