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Phenotype Image Detail
Image
Caption Tyrp1b/Tyrp1b irides at (C) 4 months, (D) 9 months, and (E) 20 months. From 1-6 months the mutant mouse eyes were indistinguishable from wild type eyes. Thereafter, the mutant mouse eyes were characterized by a gradual atrophy of iris stromal morphology. Beginning at 6 months, a population of small phagocytic clump cells began to be discernible across the iris surface. With age, the underlying vasculature became obscured, and irides appeared increasingly coarse and atrophic, particularly at the pupil margin where a narrow white band of underlying tissue was exposed. With advanced age, full-thickness iris holes occurred, but rarely before two years of age.
Copyright This image is from Anderson MG, BMC Biol 2006;4():20, an open-access article, licensee BioMed Central Ltd. J:128215
Associated
Alleles
Symbol Name
Tyrp1b tyrosinase-related protein 1; brown

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
12/04/2018
MGI 6.13
The Jackson Laboratory