Phenotype Image Detail

Image

Caption

Electron microscopical findings in dermal fibroblasts and cortical bone of AlleleSymbol(MGI:3769585|0)/Col1a1⁺ mice. A & B: Transmission electron micrographs (TEM) of wild type (left) and Col1a1^Aga2/Col1a1⁺ (right) fibroblasts. The rough endoplasmatic reticulum (rER) is enforged in Col1a1^Aga2/Col1a1⁺ cells (bars, 2um for main, 1um for inset). Increased intracellular empty vacuoles (arrow heads) and lysomes (L) were present in the mutant mice. C-F: Scanning electron micrographs (SEM) of femoral endosteal surfaces reveal differences in organization of the collagen matrix (C,D) Outer cortical surface. (E,F) Inner cortical surface.

Copyright

This image is from Lisse TS, PLoS Genet 2008;4(2):e7, and is displayed under the terms of the Creative Commons Attribution 4.0 International License. J:129569

Associated Alleles

Symbol	Name
Col1a1^Aga2	collagen, type I, alpha 1; abnormal gait 2

Associated Genotypes

Allelic Composition	Genetic Background
Col1a1^Aga2/Col1a1^+	involves: C3HeB/FeJ * C57BL/6J