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Phenotype Image Detail
Caption Hindlimbs of newborn wild type mouse (C) and newborn Bmp2tm1Cjt/Bmp2tm1Cjt Bmp4tm1Jfm/Bmp4tm1Jfm Tg(Prrx1-cre)1Cjt/0 mouse (D). E & F: Wild type and mutant respectively, showing acridine orange stained hindlimbs of E15.5 mouse embryos. Acridine orange stain is yellow. G & H: Enlarged views of selected regions from (E) and (F), respectively. Black arrows in (G) and (H) show acridine orange stained apoptotic cells in the interdigital mesenchyme, and asterisk in (H) shows the remnant of the apical ectodermal ridge (AER). I & J: Fgf8 mRNA expression in the hindlimbs of #13.5 wild type (I) and mutant (J) embryos. THe thick black arrows in (J) show Fgf8 mRNA expression.
Copyright This image is from Bandyopadhyay A, PLoS Genet 2006 Dec 22;2(12):e216, an open-access article distributed under the terms of the Creative Commons Attribution License. J:118257
Symbol Name
Bmp2tm1Cjt bone morphogenetic protein 2; targeted mutation 1, Clifford J Tabin
Bmp4tm1Jfm bone morphogenetic protein 4; targeted mutation 1, James F Martin
Tg(Prrx1-cre)1Cjt transgene insertion 1, Clifford J Tabin
Allelic Composition Genetic Background
involves: 129S4/SvJaeSor * C57BL/6 * SJL

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