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Phenotype Image Detail
Caption A: A 4 day old Hey2tm1Mtc/Hey2tm1Mtc mouse, compared with a heterozygous littermate. Wild type and heterozygotes from the same litter are indistinguishable. B-D: Hematoxylin/eosin stained section showing a large ventricular septal defect (VSD, indicated by *, B), pulmonary congestion (C), and liver congestion (D), suggesting the presence of heart failure in association with a VSD. E: Pathology of a mutant mouse that survived into adulthood but died at 12 weeks of age. Note the presence of biventricular enlargement, suggesting the presence of cardiomyopathy. F: Higher-power view of the same mutant mouse heart showing endocardial calcification and interstitial fibrosis. RV, right ventricle; LV, left ventricle.
Copyright This image is from Sakata Y, Proc Natl Acad Sci U S A 2002 Dec 10;99(25):16197-202. Copyright 2002 National Academy of Sciences, U.S.A. J:80681
Symbol Name
Hey2tm1Mtc hairy/enhancer-of-split related with YRPW motif 2; targeted mutation 1, Michael T Chin
Allelic Composition Genetic Background
Hey2tm1Mtc/Hey2tm1Mtc involves: 129X1/SvJ * C57BL/6

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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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