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Phenotype Image Detail
Image
Caption A: Typical oil red-O stained section from a 20 week old Plgtm1Jld/Plgtm1Jld mouse showing a normal vessel wall in the region around a valve cusp (arrowhead). B: Section from a 22 week Apoetm1Bres/Apoetm1Bres mouse showing a small fatty streak lesion. C & D: Sections from a 22 week old Apoetm1Bres/Apoetm1Bres Plgtm1Jld/Plgtm1Jld mouse displaying a fatty streak (C) and an advanced fibroproliferative lesion (D). Note the substantial lipid deposits deep in the medial layer (arrows) and apparent disruption (arrowhead) of elastic lamina in D. E: Typical appearance of a proximal aorta lesion in a 25 week of ApoE deficient mouse stained with hematoxylin and eosin. F: Complex lesion in the proximal aorta of a 20 week old double homozygous mouse.
Copyright This image is from Xiao Q, Proc Natl Acad Sci U S A 1997 Sep 16;94(19):10335-40. Copyright 1997 National Academy of Sciences, U.S.A. J:42927
Associated
Alleles
Symbol Name
Apoetm1Bres apolipoprotein E; targeted mutation 1, Jan L Breslow
Plgtm1Jld plasminogen; targeted mutation 1, Jay L Degen
Associated
Genotypes
Allelic Composition Genetic Background
Plgtm1Jld/Plgtm1Jld involves: 129P2/OlaHsd * C57BL/6 * NIH Black Swiss
Apoetm1Bres/Apoetm1Bres
Plgtm1Jld/Plgtm1Jld
involves: 129P2/OlaHsd * C57BL/6 * NIH Black Swiss
Apoetm1Bres/Apoetm1Bres involves: 129P2/OlaHsd * C57BL/6 * NIH Black Swiss

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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
09/09/2014
MGI 5.19
The Jackson Laboratory