Phenotype Image Detail

Image

Caption

A: Typical oil red-O stained section from a 20 week old Plg^tm1Jld/Plg^tm1Jld mouse showing a normal vessel wall in the region around a valve cusp (arrowhead). B: Section from a 22 week Apoe^tm1Bres/Apoe^tm1Bres mouse showing a small fatty streak lesion. C & D: Sections from a 22 week old Apoe^tm1Bres/Apoe^tm1Bres Plg^tm1Jld/Plg^tm1Jld mouse displaying a fatty streak (C) and an advanced fibroproliferative lesion (D). Note the substantial lipid deposits deep in the medial layer (arrows) and apparent disruption (arrowhead) of elastic lamina in D. E: Typical appearance of a proximal aorta lesion in a 25 week of ApoE deficient mouse stained with hematoxylin and eosin. F: Complex lesion in the proximal aorta of a 20 week old double homozygous mouse.

Copyright

This image is from Xiao Q, Proc Natl Acad Sci U S A 1997 Sep 16;94(19):10335-40. Copyright 1997 National Academy of Sciences, U.S.A. J:42927

Associated Alleles

Symbol	Name
Apoe^tm1Bres	apolipoprotein E; targeted mutation 1, Jan L Breslow
Plg^tm1Jld	plasminogen; targeted mutation 1, Jay L Degen

Associated Genotypes

Allelic Composition	Genetic Background
Plg^tm1Jld/Plg^tm1Jld	involves: 129P2/OlaHsd * C57BL/6 * NIH Black Swiss
Apoe^tm1Bres/Apoe^tm1Bres Plg^tm1Jld/Plg^tm1Jld	involves: 129P2/OlaHsd * C57BL/6 * NIH Black Swiss
Apoe^tm1Bres/Apoe^tm1Bres	involves: 129P2/OlaHsd * C57BL/6 * NIH Black Swiss