Phenotype Image Detail

Image

Caption

A & B: Sagittal, nondecalcified sections of incisors from a Pthlh^tm1Hmk/Pthlh^tm1Hmk Tg(Col2a1-PTHLH)2Ecw/0 neonate (B) and a wild-type littermate (A) stained with toluidine blue. A well developed ameloblast layer (a) is readily apparent on the labial aspect of the normal tooth (A), but is lacking in the mutant (B), which is crowded by the surrounding alveolar bone. The dark dentin layer (d) is intact but the adjacent enamel (e) is absent from the labial surface of the incisor (the space between the ameloblast layer and the enamel in A is a sectioning artifact). C & D: Mandibles from a 1 week old wild-type (C) and mutant mouse (D) were decalcified and then sectioned sagitally through the molar crypt. Distortion of the teeth in the mutant mouse caused by progressive impaction is readily apparent. The space between the ameloblast (a) and dentin (d) layers defines the area occupied by the enamel (e) that has been removed through decalcification. E: Magnification of an nondecalcified sagittal section through the region between the incisor and the first molar of a mandible from a mutant mouse. Ostoclasts (arrowhead) can be seen attached to the surfaces of the alveolar bone. F: Coronal sections of mandibles from neonatal mutant mice were stained for tartrate-resistant acid phosphatase acitivity. Scalebar: A & B: 64um; C,D & F: 32um; E: 16um

Copyright

This image is from Philbrick WM, Proc Natl Acad Sci U S A 1998 Sep 29;95(20):11846-51. Copyright 1998 National Academy of Sciences, U.S.A. J:50144

Associated Alleles

Symbol	Name
Tg(Col2a1-PTHLH)2Ecw	transgene insertion 2, Eleanor C Weir

Associated Genotypes

Allelic Composition	Genetic Background
Pthlh^tm1Hmk/Pthlh^tm1Hmk Tg(Col2a1-PTHLH)2Ecw/0	involves: 129S2/SvPas * C57BL/6 * SJL