Phenotype Image Detail

Image

Caption

A-C: Histological sections of placental attachment in a wild-type and two Pten^tm1Mak/⁺ embryos. The mutants show defects in chorioallantoic fusion (B) or functional placental development (C) relative to the wild-type embryo (A). D & E: Histological sections of a wild-type (D) and a moribund heterozygous (E) embryo stained for phospho-PKB. Phospho-PKB is elevated in the trophoblast layers of the developing heterozygous placenta. F & G: Histological sections of a wild-type (F) and a moribund heterozygous (G) embryo stained for phospho-Erk. Abbreviations: allantois (a); chorion (ch); giant cells (g); heart (h); maternal portion of the placenta (ma); spongiotrophoblast cells (sp).

Copyright

This image is from Cully M, Proc Natl Acad Sci U S A 2004 Oct 26;101(43):15358-63. Copyright 2004 National Academy of Sciences, U.S.A. J:93530

Associated Alleles

Symbol	Name
Pten^tm1Mak	phosphatase and tensin homolog; targeted mutation 1, Tak W Mak

Associated Genotypes

Allelic Composition	Genetic Background
Pten^tm1Mak/Pten^+	B6.129P2-Pten^tm1Mak