Phenotype Image Detail

Image

Caption

Histologic bone comparison of wild-type and Cyp27b1^tm1Dgo/Cyp27b1^tm1Dgo littermates at 4 weeks of age. A: Proximal tibial epiphysis, growth plate, and metaphysis, hematoxylin and eosin stained. B: Von Kossa stain of undermineralized sections at 4 weeks of age. Counterstaining with toluidine blue. C: Tartrate-resistant acid phosphatase (TRAP) staining of osteoclasts in the primary spongiosa. Counterstaining with methylene blue. Abbreviations: growth plate (GP); distal femur (DF); trabecular (TB); cortical bone (CB); osteiod (*) Scalebars: A (upper) 500um; (lower) 250um; B: (DF) 500um; (GP) 100um; (TB & CB) 50um C: (upper) 250um; (lower) 50um

Copyright

This image is from Panda DK, Proc Natl Acad Sci U S A 2001 Jun 19;98(13):7498-503. Copyright 2001 National Academy of Sciences, U.S.A. J:70030

Associated Alleles

Symbol	Name
Cyp27b1^tm1Dgo	cytochrome P450, family 27, subfamily b, polypeptide 1; targeted mutation 1, David Goltzman

Associated Genotypes

Allelic Composition	Genetic Background
Cyp27b1^tm1Dgo/Cyp27b1^tm1Dgo	involves: 129S1/Sv * 129X1/SvJ * BALB/c