Phenotype Image Detail

Image

Caption

A & B: Cryosections of the retina of a wild-ype (a) mouse and Cnga3^tm1Biel/Cnga3^tm1Biel (b) mouse at 2 months of age shows labelling of the outer segments of cone photoreceptors (arrows) of the wild-type mouse but no labelling of the Cnga3^tm1Biel/Cnga3^tm1Biel mouse. C & D: Detection of cone photoreceptors with the lectin peanut agglutinin in wild-type mouse and Cnga3^tm1Biel/Cnga3^tm1Biel mouse reveals a reduced number of cones in the homozygous mutant mouse (arrows). E & F: Ultrastructural localization of Cng3 on the membranous disks of a cone outer segment of a wild-type (arrows). F: Cnga3^tm1Biel/Cnga3^tm1Biel mouse showing partial degeneration of the disk structure. A rod outer segment next to the cone outer segment is indicated by *. Sections A-D were taken from the central region of the inferior-nasal section. Abbreviations: PhR: inner and outer segments of the photoreceptors; ONL: outer nuclear layer; INL: inner nuclear layer; IPL: inner plexiform layer; GCL: ganglion cell layer Scalebar: A & B: 10um; C & D: 20um E & F 0.2um

Copyright

This image is from Biel M, Proc Natl Acad Sci U S A 1999 Jun 22;96(13):7553-7. Copyright 1999 National Academy of Sciences, U.S.A. J:56020

Associated Alleles

Symbol	Name
Cnga3^tm1Biel	cyclic nucleotide gated channel alpha 3; targeted mutation 1, Martin Biel

Associated Genotypes

Allelic Composition	Genetic Background
Cnga3^tm1Biel/Cnga3^tm1Biel	involves: 129S1/Sv * 129X1/SvJ * C57BL/6