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Phenotype Image Detail
Image
Caption Panels A-C: Coronal sections through the head showing intact hard palate of E18.5 embryos of wildtype mice (A), cleft palates Fgfr2tm1Schl/Fgfr2tm1Schl (B) and Fgfr2tm2Schl/Fgfr2 (C). Panels D-F: Trachea showing cartilaginous rings in wildtype (D) however in the Fgfr2tm1Schl/Fgfr2tm1Schl and the Fgfr2tm2Schl/Fgfr2tm2Schl mice there is no seperation of the traceal cartilage into rings, and the trachea appears like a smooth cartilaginous tube. Panels G-I: The knee joints of E18.5 embryos of wild type (G) and Fgfr2tm2Schl/Fgfr2tm2Schl (I) are similar whereas the joint spaces did not form in the Fgfr2tm1Schl/Fgfr2tm1Schl (H). Panels J-L: Normal elbow joint development in the wildtype (J) and Fgfr2tm2Schl/Fgfr2tm2Schl (L), Fgfr2tm1Schl/Fgfr2tm1Schl mice (K) display agenesis of joint spaces. Abbreviations: coronoid process (C); cricoid cartilage (Cr); femur (F); fibula (Fi); humerus (Hu); hard palate (HP); nasal septum (N); olecranon process (O); patella (P); radius (R); tongue (T); tracheal cartilage rings (Tc); tibia (Ti); trochlear notch (Tr); thyroid cartilage rings (Tc); tibia (Ti); trochlear notch (Ty); thyroid cartilage (Ty) and ulna (U). Scalebars 200um.
Copyright This image is from Eswarakumar VP, Proc Natl Acad Sci U S A 2006 Dec 5;103(49):18603-8. Copyright 2006 National Academy of Sciences, U.S.A. J:118299
Associated
Alleles
Symbol Name
Fgfr2tm1Schl fibroblast growth factor receptor 2; targeted mutation 1, Joseph Schlessinger
Fgfr2tm2Schl fibroblast growth factor receptor 2; targeted mutation 2, Joseph Schlessinger
Associated
Genotypes
Allelic Composition Genetic Background
Fgfr2tm1Schl/Fgfr2tm1Schl involves: 129S1/Sv
Fgfr2tm2Schl/Fgfr2tm2Schl involves: 129S1/Sv * BALB/c * C57BL/6

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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
08/26/2014
MGI 5.19
The Jackson Laboratory