Phenotype Image Detail

Image

Caption

Fundus photographs, ERGs, and histology of eyes from Nr2e3^rd7/Nr2e3^rd7 mice at 1 month (a-c), 5 months (d-f), and 16 months (g-i) of age. At 1 month of age, Nr2e3^rd7/Nr2e3^rd7 mice have white spots over entire retina (a) but the scotopic and photopic (Inset) ERGs are normal (b), and light micrographs show photoreceptor and outer nuclear layerwaves, whorls, and rosettes in the retina (c). At about 5 months of age, the number of retinal spots is decreased (d), ERGs are still normal (e), and histology shows few retinal waves (f). By 16 months of age, attenuated retinal vessels and mottled retinal pigment indicate retinal degeneration (g), ERGs are now 50% of normal (h), and the outer nuclear layer and outer segment have degenerated to half normal (i).

Copyright

This image is from Akhmedov NB, Proc Natl Acad Sci U S A 2000 May 9;97(10):5551-6. Copyright 2000 National Academy of Sciences, U.S.A. J:62171

Associated Alleles

Symbol	Name
Nr2e3^rd7	nuclear receptor subfamily 2, group E, member 3; retinal degeneration 7

Associated Genotypes

Allelic Composition	Genetic Background
Nr2e3^rd7/Nr2e3^rd7	Not Specified