Phenotype Image Detail

Image

Caption

Panels A and B. Four week old littermates, +/+ wildtype (left) and Fgfr2^tm4Lni/⁺ (right). The Fgfr2^tm4Lni/⁺ skulls are rounded due to shortening of the rostrocaudal axis. Arrows indicate obliterated coronal and fusion of the lambdoid sutures. Arrowheads point to normal basioccipital-exoccipital-basisphenoid synchondroses in the wildtype (left) in contrast to the loss of function mutation in the precociously fused Fgfr2^tm4Lni/⁺ mouse (right). Panel C. Histological coronal suture sections frontal and parietal bones at E16.5 and obliterated suture at P29 (arrows). Abbreviations: frontal (f); parietal (p). Scalebars, 200um.

Copyright

This image is from Eswarakumar VP, Proc Natl Acad Sci U S A 2004 Aug 24;101(34):12555-60. Copyright 2004 National Academy of Sciences, U.S.A. J:92433

Associated Alleles

Symbol	Name
Fgfr2^tm4Lni	fibroblast growth factor receptor 2; targeted mutation 4, Peter Lonai

Associated Genotypes

Allelic Composition	Genetic Background
Fgfr2^tm4Lni/Fgfr2^+	Not Specified