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Gene Expression Image Detail
J:63183 Kramer PR, et al., Mech Dev. 2000 Jun;94(1-2):79-94
Caption Sections (A,C) are separated by a distance of 60 microns, the remainder are adjacent sections. In (A), high magnification of boxed region is shown in inset (upper right), while (D,F) are high magnifications of (C,E), respectively. LHRH neurons (blue-black, black arrows) are associated with peripherin fibers (A,B, brown fibers, arrowheads) in the nasal regions as well as the respiratory epithelium (re) in AP-2 a mutant mice (E14.5): note that the olfactory pit is lateral of section in A. NCAM-positive fibers (C, brown fibers) are present in the olfactory epithelium (oe), near the cribriform plate and in the ventral nasal region (boxed region: asterisk). High magnification of the box region (*) is shown in the inset (lower left). One NCAM-positive cell was within the respiratory epithelium (D, open arrowhead); note that this was the highest NCAM signal observed in the respiratory epithelium (n = 4 embryos). An LHRH cell cluster is present in the nasal septum (C, arrow) which is not associated with NCAM-positive fibers. Olf-1 staining (E, brown nuclei) was present in the olfactory epithelium and the ventral nasal region (*), but absent from this region of the respiratory epithelium (F). Bar = 200 microns (A,C,E); 50 microns (B,D,F).
Reprinted with permission from Elsevier from doi:10.1016/S0925-4773(00)00316-6 Mech Dev 94: 79-94, Kramer PR; Guerrero G; Krishnamurthy R; Mitchell PJ; Wray S, Ectopic expression of luteinizing hormone-releasing hormone and peripherin in the respiratory epithelium of mice lacking transcription factor AP-2alpha Copyright 2000
Label Assay & Result Details (Gene Symbol) Spatial Mapping
A MGI:3043831 (Gnrh1)
B MGI:3043831 (Gnrh1) MGI:3043830 (Prph)
C MGI:3043831 (Gnrh1) MGI:3043836 (Ncam1)
D MGI:3043831 (Gnrh1) MGI:3043836 (Ncam1)
E MGI:3043835 (Ebf1)
F MGI:3043835 (Ebf1)

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