Comparative GO Graph (mouse, human, rat)

• Source: HomoloGene (Release 68, May 6, 2014)
• Class ID: 89

Graphs for Molecular Function, Cellular Component, Biological Process generated Tue Aug 5 20:57:06 2014.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human and rat homologs annotated from the biomedical literature.

• This class contains
  • Human genes EDNRB
  • Mouse genes Ednrb
  • Rat genes Ednrb
• Annotations are indicated with nodes colored by organism: Human, Mouse, Rat
• Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
• GO annotations: Human from GOA; Mouse from MGI; Rat from RGD.
• Only experimental annotations are displayed: EXP, IDA, IGI, IMP, IPI. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Mouse-Rat genes in HomoloGene:89

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0004962	endothelin receptor activity	EDNRB	IDA		Human	PMID:1713452
Molecular Function	GO:0004962	endothelin receptor activity	EDNRB	IMP		Human	PMID:19767294
Molecular Function	GO:0004962	endothelin receptor activity	Ednrb	IMP	MGI:MGI:1857161	Mouse	MGI:MGI:2136077|PMID:11413164
Molecular Function	GO:0004962	endothelin receptor activity	Ednrb	IDA		Mouse	MGI:MGI:2449880|PMID:12441350
Molecular Function	GO:0004962	endothelin receptor activity	Ednrb	IDA		Rat	RGD:730808|PMID:2175397
Molecular Function	GO:0017046	peptide hormone binding	EDNRB	IPI	UniProtKB:P05305	Human	PMID:1713452
Molecular Function	GO:0017046	peptide hormone binding	EDNRB	IPI	UniProtKB:P14138	Human	PMID:1713452
Molecular Function	GO:0017046	peptide hormone binding	EDNRB	IPI	UniProtKB:P20800	Human	PMID:1713452
Molecular Function	GO:0005515	protein binding	EDNRB	IPI	UniProtKB:P05305	Human	PMID:23597562
Molecular Function	GO:0005515	protein binding	Ednrb	IPI	UniProtKB:P22387	Mouse	MGI:MGI:2449880|PMID:12441350
Molecular Function	GO:0031702	type 1 angiotensin receptor binding	Ednrb	IPI	RGD:2070	Rat	RGD:1581862|PMID:16014039
Molecular Function	GO:0031702	type 1 angiotensin receptor binding	Ednrb	IPI	RGD:2071	Rat	RGD:1581862|PMID:16014039
Cellular Component	GO:0016020	membrane	Ednrb	IDA		Rat	RGD:628459|PMID:11709437
Cellular Component	GO:0045121	membrane raft	Ednrb	IDA		Rat	RGD:4892583|PMID:18288637
Cellular Component	GO:0031965	nuclear membrane	Ednrb	IDA		Rat	RGD:1581838|PMID:12756260
Cellular Component	GO:0005886	plasma membrane	Ednrb	IDA		Rat	RGD:1581862|PMID:16014039
Biological Process	GO:0019934	cGMP-mediated signaling	Ednrb	IMP		Rat	RGD:4892585|PMID:17585504
Biological Process	GO:0048066	developmental pigmentation	Ednrb	IMP	MGI:MGI:1856149	Mouse	MGI:MGI:3055244|PMID:15322542
Biological Process	GO:0086100	endothelin receptor signaling pathway	EDNRB	IDA		Human	PMID:1713452
Biological Process	GO:0086100	endothelin receptor signaling pathway	EDNRB	IMP		Human	PMID:19767294
Biological Process	GO:0086100	endothelin receptor signaling pathway	Ednrb	IMP	MGI:MGI:1857161	Mouse	MGI:MGI:2136077|PMID:11413164
Biological Process	GO:0048484	enteric nervous system development	Ednrb	IDA		Mouse	MGI:MGI:1330409|PMID:10021336
Biological Process	GO:0048484	enteric nervous system development	Ednrb	IGI	RGD:629492	Rat	RGD:1581884|PMID:15026112
Biological Process	GO:0035645	enteric smooth muscle cell differentiation	Ednrb	IDA		Mouse	MGI:MGI:1330409|PMID:10021336
Biological Process	GO:0042045	epithelial fluid transport	Ednrb	IMP		Rat	RGD:4892575|PMID:18948426
Biological Process	GO:0007186	G-protein coupled receptor signaling pathway	Ednrb	IDA		Mouse	MGI:MGI:2449880|PMID:12441350
Biological Process	GO:0007186	G-protein coupled receptor signaling pathway	Ednrb	IGI	MGI:MGI:95768	Mouse	MGI:MGI:2449880|PMID:12441350
Biological Process	GO:0048246	macrophage chemotaxis	EDNRB	IMP		Human	PMID:12207323
Biological Process	GO:0030318	melanocyte differentiation	Ednrb	IMP	MGI:MGI:1856148	Mouse	MGI:MGI:77000|PMID:2379821
Biological Process	GO:0030318	melanocyte differentiation	Ednrb	IDA		Mouse	MGI:MGI:85072|PMID:9012511
Biological Process	GO:0030318	melanocyte differentiation	Ednrb	IDA		Rat	RGD:628459|PMID:11709437
Biological Process	GO:0043066	negative regulation of apoptotic process	Ednrb	IGI	RGD:629492	Rat	RGD:1581884|PMID:15026112
Biological Process	GO:0043066	negative regulation of apoptotic process	Ednrb	IMP		Rat	RGD:4892578|PMID:18683040
Biological Process	GO:0032269	negative regulation of cellular protein metabolic process	EDNRB	IMP		Human	PMID:19767294
Biological Process	GO:0014043	negative regulation of neuron maturation	Ednrb	IDA		Mouse	MGI:MGI:1330409|PMID:10021336
Biological Process	GO:0000122	negative regulation of transcription from RNA polymerase II promoter	EDNRB	IMP		Human	PMID:19767294
Biological Process	GO:0000122	negative regulation of transcription from RNA polymerase II promoter	Ednrb	IDA		Mouse	MGI:MGI:1330409|PMID:10021336
Biological Process	GO:0001755	neural crest cell migration	Ednrb	IMP		Mouse	MGI:MGI:1349495|PMID:10591209
Biological Process	GO:0007422	peripheral nervous system development	Ednrb	IMP	MGI:MGI:1856149	Mouse	MGI:MGI:77408|PMID:8582288
Biological Process	GO:0007200	phospholipase C-activating G-protein coupled receptor signaling pathway	Ednrb	IMP		Rat	RGD:1581866|PMID:15245872
Biological Process	GO:0043473	pigmentation	Ednrb	IMP	MGI:MGI:1856148	Mouse	MGI:MGI:77000|PMID:2379821
Biological Process	GO:0043473	pigmentation	Ednrb	IMP		Rat	RGD:628515|PMID:8570650
Biological Process	GO:0008284	positive regulation of cell proliferation	Ednrb	IMP		Rat	RGD:4892557|PMID:19628632
Biological Process	GO:0008284	positive regulation of cell proliferation	Ednrb	IMP		Rat	RGD:4892578|PMID:18683040
Biological Process	GO:0007204	positive regulation of cytosolic calcium ion concentration	Ednrb	IDA		Rat	RGD:730808|PMID:2175397
Biological Process	GO:0060406	positive regulation of penile erection	Ednrb	IMP		Rat	RGD:4892342|PMID:19884966
Biological Process	GO:0001934	positive regulation of protein phosphorylation	Ednrb	IDA		Rat	RGD:1581862|PMID:16014039
Biological Process	GO:0035815	positive regulation of renal sodium excretion	Ednrb	IMP		Rat	RGD:4892582|PMID:18305094
Biological Process	GO:0035810	positive regulation of urine volume	Ednrb	IMP		Rat	RGD:4892582|PMID:18305094
Biological Process	GO:0007497	posterior midgut development	Ednrb	IMP	MGI:MGI:1856149	Mouse	MGI:MGI:77408|PMID:8582288
Biological Process	GO:0008217	regulation of blood pressure	Ednrb	IMP	MGI:MGI:1857161	Mouse	MGI:MGI:1352592|PMID:10626068
Biological Process	GO:0008217	regulation of blood pressure	Ednrb	IMP		Rat	RGD:1601009|PMID:16763077
Biological Process	GO:0050678	regulation of epithelial cell proliferation	Ednrb	IMP		Rat	RGD:1581844|PMID:12538737
Biological Process	GO:0031620	regulation of fever generation	Ednrb	IMP		Rat	RGD:1581859|PMID:16123229
Biological Process	GO:0006885	regulation of pH	Ednrb	IMP	MGI:MGI:1857161	Mouse	MGI:MGI:2136077|PMID:11413164
Biological Process	GO:0051930	regulation of sensory perception of pain	Ednrb	IMP		Rat	RGD:1581889|PMID:12847519
Biological Process	GO:0032496	response to lipopolysaccharide	Ednrb	IMP		Rat	RGD:4892334|PMID:20888431
Biological Process	GO:0048265	response to pain	Ednrb	IMP		Rat	RGD:1581889|PMID:12847519
Biological Process	GO:0019233	sensory perception of pain	Ednrb	IMP		Rat	RGD:4892337|PMID:20450894
Biological Process	GO:0042310	vasoconstriction	EDNRB	IMP		Human	PMID:8982507
Biological Process	GO:0042310	vasoconstriction	Ednrb	IMP		Rat	RGD:1581832|PMID:14678950
Biological Process	GO:0042311	vasodilation	Ednrb	IMP		Rat	RGD:1581832|PMID:14678950
Biological Process	GO:0014826	vein smooth muscle contraction	EDNRB	IMP		Human	PMID:8982507

Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment

  IDA Inferred from direct assay

  IGI Inferred from genetic interaction

  IMP Inferred from mutant phenotype

  IPI Inferred from physical interaction