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Comparative GO Graph (mouse, human, rat)
Source
Class ID
HomoloGene (Release 68, May 6, 2014)
68073

Compare experimental GO annotations for Human-Mouse-Rat HomoloGene:68073

Graphs for Molecular Function, Cellular Component, Biological Process generated Tue Aug 5 20:57:06 2014.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human and rat homologs annotated from the biomedical literature.

Molecular Function


Cellular Component


Biological Process



Full set of experimental annotations for Human-Mouse-Rat genes in HomoloGene:68073
Category ID Classification term Gene Evidence Inferred from Organism Reference
Molecular FunctionGO:00718861-(4-iodo-2,5-dimethoxyphenyl)propan-2-amine bindingHTR2AIDAHumanPMID:19057895
Molecular FunctionGO:0008144drug bindingHTR2AIDAHumanPMID:15831837
Molecular FunctionGO:0008144drug bindingHTR2AIDAHumanPMID:15862800
Molecular FunctionGO:0008144drug bindingHTR2AIDAHumanPMID:18703043
Molecular FunctionGO:0001965G-protein alpha-subunit bindingHtr2aIMPRatRGD:5133450|PMID:19016481
Molecular FunctionGO:0005515protein bindingHtr2aIPIRGD:2505|RGD:68424RatRGD:7257680|PMID:20531396
Molecular FunctionGO:0005515protein bindingHtr2aIPIUniProtKB:P31421RatRGD:8553550|PMID:19590495
Molecular FunctionGO:0005515protein bindingHtr2aIPIUniProtKB:P31421RatPMID:19590495
Molecular FunctionGO:0032403protein complex bindingHtr2aIPIRGD:2280|RGD:2953RatRGD:1582161|PMID:16527989
Molecular FunctionGO:0051378serotonin bindingHTR2AIDAHumanPMID:15831837
Molecular FunctionGO:0051378serotonin bindingHTR2AIDAHumanPMID:15862800
Molecular FunctionGO:0051378serotonin bindingHTR2AIDAHumanPMID:19057895
Molecular FunctionGO:0051378serotonin bindingHTR2AIDAHumanPMID:7582481
Molecular FunctionGO:0051378serotonin bindingHtr2aIDARatRGD:5133450|PMID:19016481
Molecular FunctionGO:0004993serotonin receptor activityHTR2AIDAHumanPMID:15862800
Molecular FunctionGO:0004993serotonin receptor activityHTR2AIDAHumanPMID:7582481
Molecular FunctionGO:0004993serotonin receptor activityHtr2aIDARatRGD:5133450|PMID:19016481
Cellular ComponentGO:0070852cell body fiberHtr2aIDARatRGD:7257659|PMID:23390419
Cellular ComponentGO:0005737cytoplasmHtr2aIDARatRGD:1624400|PMID:10379914
Cellular ComponentGO:0005829cytosolHtr2aIDARatRGD:1601365|PMID:14534355
Cellular ComponentGO:0030425dendriteHtr2aIDARatRGD:1624398|PMID:10524335
Cellular ComponentGO:0043198dendritic shaftHtr2aIDARatRGD:2303638|PMID:18622042
Cellular ComponentGO:0016020membraneHtr2aIDARatRGD:5133450|PMID:19016481
Cellular ComponentGO:0043025neuronal cell bodyHtr2aIDARatRGD:7257659|PMID:23390419
Cellular ComponentGO:0005886plasma membraneHTR2AIDAHumanPMID:15862800
Cellular ComponentGO:0005886plasma membraneHTR2AIDAHumanPMID:18703043
Cellular ComponentGO:0005886plasma membraneHtr2aIDARatRGD:1601365|PMID:14534355
Biological ProcessGO:0007202activation of phospholipase C activityHTR2AIDAHumanPMID:16517693
Biological ProcessGO:0014824artery smooth muscle contractionHtr2aIMPRatRGD:7257678|PMID:14752059
Biological ProcessGO:0048148behavioral response to cocaineHtr2aIDARatRGD:7257659|PMID:23390419
Biological ProcessGO:0008219cell deathHtr2aIMPRatRGD:1624391|PMID:16504407
Biological ProcessGO:0006874cellular calcium ion homeostasisHTR2AIDAHumanPMID:16517693
Biological ProcessGO:0006874cellular calcium ion homeostasisHTR2AIDAHumanPMID:19057895
Biological ProcessGO:0050966detection of mechanical stimulus involved in sensory perception of painHtr2aIMPRatRGD:7257680|PMID:20531396
Biological ProcessGO:0050965detection of temperature stimulus involved in sensory perception of painHtr2aIMPRatRGD:7257680|PMID:20531396
Biological ProcessGO:0007186G-protein coupled receptor signaling pathwayHtr2aIDARatRGD:5133450|PMID:19016481
Biological ProcessGO:0007613memoryHtr2aIMPRatRGD:1624394|PMID:16149040
Biological ProcessGO:0043267negative regulation of potassium ion transportHtr2aIMPRatRGD:1582161|PMID:16527989
Biological ProcessGO:0051967negative regulation of synaptic transmission, glutamatergicHtr2aIMPRatRGD:1624386|PMID:17016851
Biological ProcessGO:0014065phosphatidylinositol 3-kinase signalingHTR2AIDAHumanPMID:16517693
Biological ProcessGO:0007208phospholipase C-activating serotonin receptor signaling pathwayHtr2aIDARatRGD:1624387|PMID:17010161
Biological ProcessGO:0008284positive regulation of cell proliferationHtr2aIMPRatRGD:1624373|PMID:15087293
Biological ProcessGO:0007204positive regulation of cytosolic calcium ion concentrationHtr2aIMPRatRGD:7257680|PMID:20531396
Biological ProcessGO:0070374positive regulation of ERK1 and ERK2 cascadeHTR2AIDAHumanPMID:19057895
Biological ProcessGO:0045600positive regulation of fat cell differentiationHtr2aIMPMouseMGI:MGI:5316944|PMID:20719859
Biological ProcessGO:0045821positive regulation of glycolytic processHtr2aIMPMouseMGI:MGI:3766710|PMID:17408640
Biological ProcessGO:0033674positive regulation of kinase activityHtr2aIMPMouseMGI:MGI:3766886|PMID:17720578
Biological ProcessGO:0043406positive regulation of MAP kinase activityHtr2aIMPRatRGD:1624373|PMID:15087293
Biological ProcessGO:0050731positive regulation of peptidyl-tyrosine phosphorylationHtr2aIMPMouseMGI:MGI:3766886|PMID:17720578
Biological ProcessGO:0010513positive regulation of phosphatidylinositol biosynthetic processHTR2AIDAHumanPMID:19057895
Biological ProcessGO:0045907positive regulation of vasoconstrictionHtr2aIMPRatRGD:1582161|PMID:16527989
Biological ProcessGO:0044380protein localization to cytoskeletonHtr2aIDAMouseMGI:MGI:3766886|PMID:17720578
Biological ProcessGO:0014059regulation of dopamine secretionHtr2aIMPRatRGD:1624397|PMID:15999145
Biological ProcessGO:0051209release of sequestered calcium ion into cytosolHTR2AIDAHumanPMID:15862800
Biological ProcessGO:0051209release of sequestered calcium ion into cytosolHTR2AIMPHumanPMID:18703043
Biological ProcessGO:0042493response to drugHTR2AIDAHumanPMID:15862800
Biological ProcessGO:0042493response to drugHTR2AIDAHumanPMID:18703043
Biological ProcessGO:0042493response to drugHtr2aIMPRatRGD:1624381|PMID:17077317
Biological ProcessGO:0019233sensory perception of painHtr2aIMPRatRGD:1624390|PMID:16527395
Biological ProcessGO:0007210serotonin receptor signaling pathwayHTR2AIMPHumanPMID:18703043
Biological ProcessGO:0030431sleepHtr2aIMPRatRGD:1624384|PMID:17059817
Biological ProcessGO:0001659temperature homeostasisHtr2aIMPRatRGD:1624383|PMID:17067560
Biological ProcessGO:0014832urinary bladder smooth muscle contractionHtr2aIMPRatRGD:7257664|PMID:23274492

Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment
  IDA Inferred from direct assay
  IGI Inferred from genetic interaction
  IMP Inferred from mutant phenotype
  IPI Inferred from physical interaction

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
08/12/2014
MGI 5.19
The Jackson Laboratory