Comparative GO Graph (mouse, human, rat)

• Source: HomoloGene (Release 68, May 6, 2014)
• Class ID: 55719

Graphs for Molecular Function, Cellular Component, Biological Process generated Tue Apr 25 11:11:33 2017.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human and rat homologs annotated from the biomedical literature.

• This class contains
  • Human genes CDKL5
  • Mouse genes Cdkl5
  • Rat genes Cdkl5
• Annotations are indicated with nodes colored by organism: Human, Mouse, Rat
• Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
• GO annotations: Human from GOA; Mouse from MGI; Rat from RGD.
• Only experimental annotations are displayed: EXP, IDA, IGI, IMP, IPI. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Mouse-Rat genes in HomoloGene:55719

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0005524	ATP binding	CDKL5	IDA		Human	PMID:16935860
Molecular Function	GO:0016301	kinase activity	CDKL5	IDA		Human	PMID:15917271
Molecular Function	GO:0005515	protein binding	Cdkl5	IPI	RGD:68424	Rat	RGD:12791021|PMID:23671101
Molecular Function	GO:0004672	protein kinase activity	CDKL5	IDA		Human	PMID:16935860
Molecular Function	GO:0048365	Rac GTPase binding	Cdkl5	IPI	UniProtKB:Q6RUV5	Rat	RGD:8554575|PMID:20861382
Cellular Component	GO:0005829	cytosol	CDKL5	IDA		Human	GO_REF:0000052
Cellular Component	GO:0032839	dendrite cytoplasm	Cdkl5	IDA		Rat	RGD:8554575|PMID:20861382
Cellular Component	GO:0044294	dendritic growth cone	Cdkl5	IDA		Rat	RGD:8554575|PMID:20861382
Cellular Component	GO:0005654	nucleoplasm	CDKL5	IDA		Human	GO_REF:0000052
Cellular Component	GO:0005634	nucleus	CDKL5	IDA		Human	PMID:16935860
Cellular Component	GO:0048471	perinuclear region of cytoplasm	Cdkl5	IDA		Rat	RGD:12791021|PMID:23671101
Cellular Component	GO:0032587	ruffle membrane	Cdkl5	IDA		Rat	RGD:8554575|PMID:20861382
Cellular Component	GO:0045202	synapse	Cdkl5	IDA		Rat	RGD:12791021|PMID:23671101
Biological Process	GO:0001764	neuron migration	Cdkl5	IMP		Rat	RGD:8554575|PMID:20861382
Biological Process	GO:0045773	positive regulation of axon extension	Cdkl5	IMP		Rat	RGD:8554575|PMID:20861382
Biological Process	GO:0050775	positive regulation of dendrite morphogenesis	Cdkl5	IMP		Rat	RGD:8554575|PMID:20861382
Biological Process	GO:0060999	positive regulation of dendritic spine development	Cdkl5	IMP		Rat	RGD:12791021|PMID:23671101
Biological Process	GO:0043547	positive regulation of GTPase activity	Cdkl5	IMP		Rat	RGD:8554575|PMID:20861382
Biological Process	GO:0046777	protein autophosphorylation	CDKL5	IDA		Human	PMID:16935860
Biological Process	GO:0050773	regulation of dendrite development	Cdkl5	IMP		Rat	RGD:8554575|PMID:20861382

Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment

  IDA Inferred from direct assay

  IGI Inferred from genetic interaction

  IMP Inferred from mutant phenotype

  IPI Inferred from physical interaction