About   Help   FAQ
Comparative GO Graph (mouse, human, rat)
Source
Class ID
HomoloGene (Release 68, May 6, 2014)
478

Compare experimental GO annotations for Human-Mouse-Rat HomoloGene:478

Graphs for Molecular Function, Cellular Component, Biological Process generated Tue Apr 25 11:11:33 2017.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human and rat homologs annotated from the biomedical literature.

Molecular Function


Cellular Component


Biological Process



Full set of experimental annotations for Human-Mouse-Rat genes in HomoloGene:478
Category ID Classification term Gene Evidence Inferred from Organism Reference
Molecular FunctionGO:0005125cytokine activityIl10IMPMGI:MGI:1857199MouseMGI:MGI:3051177|PMID:15240714
Molecular FunctionGO:0005125cytokine activityIl10IDAMouseMGI:MGI:3033882|PMID:11027433
Molecular FunctionGO:0005141interleukin-10 receptor bindingIl10IMPRatRGD:2311043|PMID:19428551
Molecular FunctionGO:0005141interleukin-10 receptor bindingIl10IDARatRGD:729323|PMID:12405978
Molecular FunctionGO:0005515protein bindingIL10IPIUniProtKB:Q13651HumanPMID:11485736
Molecular FunctionGO:0005515protein bindingIL10IPIUniProtKB:Q13651HumanPMID:12513909
Cellular ComponentGO:0005615extracellular spaceIL10IDAHumanPMID:10443688
Cellular ComponentGO:0005615extracellular spaceIL10IDAHumanPMID:21323571
Cellular ComponentGO:0005615extracellular spaceIl10IDAMouseMGI:MGI:3050756|PMID:15220916
Cellular ComponentGO:0005615extracellular spaceIl10IDAMouseMGI:MGI:3839525|PMID:19139201
Cellular ComponentGO:0005615extracellular spaceIl10IDAMouseMGI:MGI:1347429|PMID:10545106
Cellular ComponentGO:0005615extracellular spaceIl10IDAMouseMGI:MGI:3051177|PMID:15240714
Cellular ComponentGO:0005615extracellular spaceIl10IDAMouseMGI:MGI:1861065|PMID:10899905
Cellular ComponentGO:0005615extracellular spaceIl10IDAMouseMGI:MGI:1861073|PMID:10940872
Cellular ComponentGO:0005615extracellular spaceIl10IDAMouseMGI:MGI:5562512|PMID:23892723
Cellular ComponentGO:0005615extracellular spaceIl10IDAMouseMGI:MGI:3694583|PMID:17137799
Cellular ComponentGO:0005615extracellular spaceIl10IDAMouseMGI:MGI:3686795|PMID:16949315
Cellular ComponentGO:0005615extracellular spaceIl10IDAMouseMGI:MGI:3695768|PMID:16275384
Cellular ComponentGO:0005615extracellular spaceIl10IDARatRGD:2308945|PMID:18787467
Biological ProcessGO:0060670branching involved in labyrinthine layer morphogenesisIl10IMPMGI:MGI:1857199MouseMGI:MGI:3664708|PMID:12842419
Biological ProcessGO:0035729cellular response to hepatocyte growth factor stimulusIl10IDAMouseMGI:MGI:4849876|PMID:21072211
Biological ProcessGO:0071222cellular response to lipopolysaccharideIl10IDAMouseMGI:MGI:3828894|PMID:19047410
Biological ProcessGO:0071222cellular response to lipopolysaccharideIl10IDAMouseMGI:MGI:5013871|PMID:21609717
Biological ProcessGO:0042742defense response to bacteriumIl10IDAMouseMGI:MGI:1861065|PMID:10899905
Biological ProcessGO:0042832defense response to protozoanIl10IDAMouseMGI:MGI:3828894|PMID:19047410
Biological ProcessGO:0006955immune responseIl10IMPRatRGD:729048|PMID:8484757
Biological ProcessGO:0006954inflammatory responseIL10IDAHumanPMID:10443688
Biological ProcessGO:0043066negative regulation of apoptotic processIl10IMPRatRGD:2306926|PMID:19395591
Biological ProcessGO:0030889negative regulation of B cell proliferationIL10IDAHumanPMID:9184696
Biological ProcessGO:0008285negative regulation of cell proliferationIl10IMPMouseMGI:MGI:5796069|PMID:26808574
Biological ProcessGO:0002875negative regulation of chronic inflammatory response to antigenic stimulusIl10IMPMGI:MGI:1857199MouseMGI:MGI:3774790|PMID:12452830
Biological ProcessGO:0060302negative regulation of cytokine activityIL10IMPHumanPMID:9847016
Biological ProcessGO:0001818negative regulation of cytokine productionIl10IMPRatRGD:729048|PMID:8484757
Biological ProcessGO:0002740negative regulation of cytokine secretion involved in immune responseIL10IDAHumanPMID:10443688
Biological ProcessGO:2000352negative regulation of endothelial cell apoptotic processIl10IGIUniProtKB:P06804MouseMGI:MGI:5796069|PMID:26808574
Biological ProcessGO:0044130negative regulation of growth of symbiont in hostIl10IMPMGI:MGI:1857199MouseMGI:MGI:3774790|PMID:12452830
Biological ProcessGO:0034115negative regulation of heterotypic cell-cell adhesionIl10IGIUniProtKB:P06804MouseMGI:MGI:5796069|PMID:26808574
Biological ProcessGO:0050728negative regulation of inflammatory responseIl10IMPMouseMGI:MGI:3790904|PMID:18270204
Biological ProcessGO:0050728negative regulation of inflammatory responseIl10IDARatRGD:1598631|PMID:17017555
Biological ProcessGO:0032689negative regulation of interferon-gamma productionIl10IMPMGI:MGI:1857199MouseMGI:MGI:3774790|PMID:12452830
Biological ProcessGO:0032695negative regulation of interleukin-12 productionIl10IMPMGI:MGI:1857199MouseMGI:MGI:3051177|PMID:15240714
Biological ProcessGO:0032715negative regulation of interleukin-6 productionIL10IDAHumanPMID:10443688
Biological ProcessGO:0051045negative regulation of membrane protein ectodomain proteolysisIL10IDAHumanPMID:18383040
Biological ProcessGO:0030886negative regulation of myeloid dendritic cell activationIl10IMPMGI:MGI:1857199MouseMGI:MGI:3051177|PMID:15240714
Biological ProcessGO:0045019negative regulation of nitric oxide biosynthetic processIl10IDARatRGD:1598631|PMID:17017555
Biological ProcessGO:1904057negative regulation of sensory perception of painIl10IDARatRGD:11049468|PMID:25078297
Biological ProcessGO:0042536negative regulation of tumor necrosis factor biosynthetic processIl10IDARatRGD:1598631|PMID:17017555
Biological ProcessGO:0032720negative regulation of tumor necrosis factor productionIl10IMPMGI:MGI:1857199MouseMGI:MGI:3774790|PMID:12452830
Biological ProcessGO:1904706negative regulation of vascular smooth muscle cell proliferationIl10IGIUniProtKB:P06804MouseMGI:MGI:5796069|PMID:26808574
Biological ProcessGO:0002904positive regulation of B cell apoptotic processIL10IDAHumanPMID:9184696
Biological ProcessGO:0045787positive regulation of cell cycleIl10IGIUniProtKB:P06804MouseMGI:MGI:5796069|PMID:26808574
Biological ProcessGO:0050715positive regulation of cytokine secretionIL10IDAHumanPMID:10443688
Biological ProcessGO:0001938positive regulation of endothelial cell proliferationIl10IGIUniProtKB:P06804MouseMGI:MGI:5796069|PMID:26808574
Biological ProcessGO:0043032positive regulation of macrophage activationIl10IDARatRGD:11049473|PMID:25837415
Biological ProcessGO:0045348positive regulation of MHC class II biosynthetic processIl10IDAMouseMGI:MGI:3033882|PMID:11027433
Biological ProcessGO:0051091positive regulation of sequence-specific DNA binding transcription factor activityIL10IDAHumanPMID:7749983
Biological ProcessGO:0045944positive regulation of transcription from RNA polymerase II promoterIl10IDAMouseMGI:MGI:3044839|PMID:15187136
Biological ProcessGO:0045893positive regulation of transcription, DNA-templatedIL10IDAHumanPMID:7749983
Biological ProcessGO:0032800receptor biosynthetic processIL10IDAHumanPMID:10443688
Biological ProcessGO:0010468regulation of gene expressionIL10IDAHumanPMID:9184696
Biological ProcessGO:1903034regulation of response to woundingIl10IMPMouseMGI:MGI:5796069|PMID:26808574
Biological ProcessGO:0051930regulation of sensory perception of painIl10IDARatRGD:1598632|PMID:16949747
Biological ProcessGO:0050807regulation of synapse organizationIl10IDARatRGD:11049480|PMID:24278397
Biological ProcessGO:0051384response to glucocorticoidIL10IDAHumanPMID:10443688
Biological ProcessGO:0002237response to molecule of bacterial originIL10IDAHumanPMID:17449476

Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment
  IDA Inferred from direct assay
  IGI Inferred from genetic interaction
  IMP Inferred from mutant phenotype
  IPI Inferred from physical interaction

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
Citing These Resources
Funding Information
Warranty Disclaimer & Copyright Notice
Send questions and comments to User Support.
last database update
08/13/2019
MGI 6.14
The Jackson Laboratory