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Comparative GO Graph (mouse, human, rat)
Source
Class ID
HomoloGene (Release 68, May 6, 2014)
4380

Compare experimental GO annotations for Human-Mouse-Rat HomoloGene:4380

Graphs for Molecular Function, Cellular Component, Biological Process generated Tue Apr 25 11:11:33 2017.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human and rat homologs annotated from the biomedical literature.

Molecular Function


Cellular Component


Biological Process



Full set of experimental annotations for Human-Mouse-Rat genes in HomoloGene:4380
Category ID Classification term Gene Evidence Inferred from Organism Reference
Molecular FunctionGO:0033613activating transcription factor bindingWfs1IPIUniProtKB:G3V909RatRGD:10047363|PMID:20160352
Molecular FunctionGO:0051117ATPase bindingWFS1IPIUniProtKB:P05026HumanPMID:17947299
Molecular FunctionGO:0051117ATPase bindingWfs1IDAMouseMGI:MGI:3794026|PMID:17947299
Molecular FunctionGO:0048306calcium-dependent protein bindingWfs1IMPRatRGD:7207844|PMID:19292454
Molecular FunctionGO:0005516calmodulin bindingWfs1IMPRatRGD:7207844|PMID:19292454
Molecular FunctionGO:0005515protein bindingWFS1IPIUniProtKB:P54274HumanPMID:21044950
Molecular FunctionGO:0031625ubiquitin protein ligase bindingWFS1IDAHumanPMID:20160352
Molecular FunctionGO:0031625ubiquitin protein ligase bindingWfs1IPIUniProtKB:B2RYC4RatRGD:10047363|PMID:20160352
Cellular ComponentGO:0005783endoplasmic reticulumWfs1IDAMouseMGI:MGI:5009410|PMID:16087305
Cellular ComponentGO:0030176integral component of endoplasmic reticulum membraneWFS1IDAHumanPMID:11181571
Cellular ComponentGO:0030176integral component of endoplasmic reticulum membraneWFS1IDAHumanPMID:14527944
Cellular ComponentGO:0000502proteasome complexWfs1IDARatRGD:10047363|PMID:20160352
Biological ProcessGO:0055074calcium ion homeostasisWFS1IDAHumanPMID:14527944
Biological ProcessGO:0032469endoplasmic reticulum calcium ion homeostasisWFS1IDAHumanPMID:16989814
Biological ProcessGO:0030968endoplasmic reticulum unfolded protein responseWfs1IMPMouseMGI:MGI:3629256|PMID:16571599
Biological ProcessGO:0042593glucose homeostasisWFS1IMPHumanPMID:9817917
Biological ProcessGO:0001822kidney developmentWFS1IMPHumanPMID:9817917
Biological ProcessGO:1903892negative regulation of ATF6-mediated unfolded protein responseWFS1IDAHumanPMID:20160352
Biological ProcessGO:1903892negative regulation of ATF6-mediated unfolded protein responseWfs1IGIUniProtKB:G3V909RatRGD:10047363|PMID:20160352
Biological ProcessGO:1902236negative regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathwayWfs1IMPMouseMGI:MGI:3629256|PMID:16571599
Biological ProcessGO:0043524negative regulation of neuron apoptotic processWFS1IMPHumanPMID:9771706
Biological ProcessGO:0043524negative regulation of neuron apoptotic processWFS1IMPHumanPMID:9817917
Biological ProcessGO:0043069negative regulation of programmed cell deathWFS1IMPHumanPMID:9771706
Biological ProcessGO:0043433negative regulation of sequence-specific DNA binding transcription factor activityWFS1IDAHumanPMID:20160352
Biological ProcessGO:0043433negative regulation of sequence-specific DNA binding transcription factor activityWfs1IGIUniProtKB:G3V909RatRGD:10047363|PMID:20160352
Biological ProcessGO:0000122negative regulation of transcription from RNA polymerase II promoterWFS1IDAHumanPMID:20160352
Biological ProcessGO:0000122negative regulation of transcription from RNA polymerase II promoterWfs1IMPRatRGD:10047363|PMID:20160352
Biological ProcessGO:2000675negative regulation of type B pancreatic cell apoptotic processWFS1IMPHumanPMID:16087305
Biological ProcessGO:2000675negative regulation of type B pancreatic cell apoptotic processWfs1IMPMouseMGI:MGI:3629256|PMID:16571599
Biological ProcessGO:2000675negative regulation of type B pancreatic cell apoptotic processWfs1IMPMouseMGI:MGI:5009410|PMID:16087305
Biological ProcessGO:0050877neurological system processWFS1IMPHumanPMID:9817917
Biological ProcessGO:0045762positive regulation of adenylate cyclase activityWfs1IMPMouseMGI:MGI:5488685|PMID:22983116
Biological ProcessGO:0051928positive regulation of calcium ion transportWFS1IDAHumanPMID:16989814
Biological ProcessGO:0045927positive regulation of growthWfs1IMPMouseMGI:MGI:4437405|PMID:19293327
Biological ProcessGO:0051247positive regulation of protein metabolic processWFS1IDAHumanPMID:17947299
Biological ProcessGO:0031398positive regulation of protein ubiquitinationWFS1IDAHumanPMID:20160352
Biological ProcessGO:0031398positive regulation of protein ubiquitinationWfs1IMPMouseMGI:MGI:5009360|PMID:20160352
Biological ProcessGO:0050821protein stabilizationWFS1IDAHumanPMID:20160352
Biological ProcessGO:0050821protein stabilizationWfs1IMPMouseMGI:MGI:5009360|PMID:20160352
Biological ProcessGO:0050821protein stabilizationWfs1IMPRatRGD:10047363|PMID:20160352
Biological ProcessGO:0003091renal water homeostasisWFS1IMPHumanPMID:9817917
Biological ProcessGO:0034976response to endoplasmic reticulum stressWFS1IDAHumanPMID:15994758
Biological ProcessGO:0034976response to endoplasmic reticulum stressWfs1IDAMouseMGI:MGI:5009413|PMID:15994758
Biological ProcessGO:0007605sensory perception of soundWFS1IMPHumanPMID:17492394
Biological ProcessGO:0030433ubiquitin-dependent ERAD pathwayWFS1IDAHumanPMID:20160352
Biological ProcessGO:0030433ubiquitin-dependent ERAD pathwayWfs1IMPMouseMGI:MGI:5009360|PMID:20160352
Biological ProcessGO:0007601visual perceptionWFS1IMPHumanPMID:9771706
Biological ProcessGO:0007601visual perceptionWFS1IMPHumanPMID:9817917

Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment
  IDA Inferred from direct assay
  IGI Inferred from genetic interaction
  IMP Inferred from mutant phenotype
  IPI Inferred from physical interaction

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
06/30/2020
MGI 6.15
The Jackson Laboratory